PMID- 1751410
OWN - NLM
STAT- MEDLINE
DCOM- 19920127
LR  - 20061115
IS  - 1044-9523 (Print)
IS  - 1044-9523 (Linking)
VI  - 2
IP  - 9
DP  - 1991 Sep
TI  - Overexpression of the retinoblastoma gene in a familial adrenocortical carcinoma.
PG  - 439-45
AB  - Tumors derived from a Li-Fraumeni syndrome cancer-susceptible family were 
      examined for expression of the retinoblastoma susceptibility gene (RB). Whereas 
      RB expression was normal in a primary breast carcinoma and its metastases from 
      one member of this family, overexpression of RB was found in an adrenocortical 
      carcinoma from another family member. This was in contrast to normal RB 
      expression in normal tissue of this patient, the adrenocortical adenocarcinoma 
      cell line SW-13, and the fibroblast cell line MRC-5, and low level RB expression 
      in normal adrenal tissue. The overexpression in the adrenocortical carcinoma 
      resulted in increased synthesis of the RB-encoded protein and did not appear to 
      be associated with RB amplification or rearrangement. This result is novel as it 
      is usually the loss of expression or production of an altered RB transcript 
      exhibiting deletions that is associated with carcinogenesis. In light of the 
      recent discovery of p53 point mutations in the affected Li-Fraumeni syndrome 
      family members tested, RB overexpression may constitute a secondary event in 
      Li-Fraumeni syndrome tumorigenesis.
FAU - Warneford, S
AU  - Warneford S
AD  - Leukemia Research and Viral Pathology Unit, Children's Hospital, Camperdown, 
      Sydney, Australia.
FAU - Townsend, M
AU  - Townsend M
FAU - Rowe, P B
AU  - Rowe PB
FAU - Dalla-Pozza, L
AU  - Dalla-Pozza L
FAU - Symonds, G
AU  - Symonds G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell Growth Differ
JT  - Cell growth & differentiation : the molecular biology journal of the American 
      Association for Cancer Research
JID - 9100024
SB  - IM
GS  - RB
MH  - Adrenal Cortex Neoplasms/*genetics/pathology
MH  - Adult
MH  - Bone Neoplasms/secondary
MH  - Breast Neoplasms/pathology
MH  - Carcinoma/*genetics/pathology
MH  - Cell Line
MH  - Child, Preschool
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Li-Fraumeni Syndrome/*genetics
MH  - Male
MH  - Pedigree
MH  - Retinoblastoma/*genetics
MH  - Tumor Cells, Cultured
EDAT- 1991/09/01 00:00
MHDA- 1991/09/01 00:01
CRDT- 1991/09/01 00:00
PHST- 1991/09/01 00:00 [pubmed]
PHST- 1991/09/01 00:01 [medline]
PHST- 1991/09/01 00:00 [entrez]
PST - ppublish
SO  - Cell Growth Differ. 1991 Sep;2(9):439-45.