PMID- 17515920
OWN - NLM
STAT- MEDLINE
DCOM- 20070731
LR  - 20220224
IS  - 1476-4687 (Electronic)
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 447
IP  - 7147
DP  - 2007 Jun 21
TI  - Chromosomally unstable mouse tumours have genomic alterations similar to diverse 
      human cancers.
PG  - 966-71
AB  - Highly rearranged and mutated cancer genomes present major challenges in the 
      identification of pathogenetic events driving the neoplastic transformation 
      process. Here we engineered lymphoma-prone mice with chromosomal instability to 
      assess the usefulness of mouse models in cancer gene discovery and the extent of 
      cross-species overlap in cancer-associated copy number aberrations. Along with 
      targeted re-sequencing, our comparative oncogenomic studies identified FBXW7 and 
      PTEN to be commonly deleted both in murine lymphomas and in human T-cell acute 
      lymphoblastic leukaemia/lymphoma (T-ALL). The murine cancers acquire widespread 
      recurrent amplifications and deletions targeting loci syntenic to those not only 
      in human T-ALL but also in diverse human haematopoietic, mesenchymal and 
      epithelial tumours. These results indicate that murine and human tumours 
      experience common biological processes driven by orthologous genetic events in 
      their malignant evolution. The highly concordant nature of genomic events 
      encourages the use of genomically unstable murine cancer models in the discovery 
      of biological driver events in the human oncogenome.
FAU - Maser, Richard S
AU  - Maser RS
AD  - Department of Medical Oncology, Dana Farber Cancer Institute, Boston, 
      Massachusetts 02115, USA.
FAU - Choudhury, Bhudipa
AU  - Choudhury B
FAU - Campbell, Peter J
AU  - Campbell PJ
FAU - Feng, Bin
AU  - Feng B
FAU - Wong, Kwok-Kin
AU  - Wong KK
FAU - Protopopov, Alexei
AU  - Protopopov A
FAU - O'Neil, Jennifer
AU  - O'Neil J
FAU - Gutierrez, Alejandro
AU  - Gutierrez A
FAU - Ivanova, Elena
AU  - Ivanova E
FAU - Perna, Ilana
AU  - Perna I
FAU - Lin, Eric
AU  - Lin E
FAU - Mani, Vidya
AU  - Mani V
FAU - Jiang, Shan
AU  - Jiang S
FAU - McNamara, Kate
AU  - McNamara K
FAU - Zaghlul, Sara
AU  - Zaghlul S
FAU - Edkins, Sarah
AU  - Edkins S
FAU - Stevens, Claire
AU  - Stevens C
FAU - Brennan, Cameron
AU  - Brennan C
FAU - Martin, Eric S
AU  - Martin ES
FAU - Wiedemeyer, Ruprecht
AU  - Wiedemeyer R
FAU - Kabbarah, Omar
AU  - Kabbarah O
FAU - Nogueira, Cristina
AU  - Nogueira C
FAU - Histen, Gavin
AU  - Histen G
FAU - Aster, Jon
AU  - Aster J
FAU - Mansour, Marc
AU  - Mansour M
FAU - Duke, Veronique
AU  - Duke V
FAU - Foroni, Letizia
AU  - Foroni L
FAU - Fielding, Adele K
AU  - Fielding AK
FAU - Goldstone, Anthony H
AU  - Goldstone AH
FAU - Rowe, Jacob M
AU  - Rowe JM
FAU - Wang, Yaoqi A
AU  - Wang YA
FAU - Look, A Thomas
AU  - Look AT
FAU - Stratton, Michael R
AU  - Stratton MR
FAU - Chin, Lynda
AU  - Chin L
FAU - Futreal, P Andrew
AU  - Futreal PA
FAU - DePinho, Ronald A
AU  - DePinho RA
LA  - eng
SI  - GEO/GSE7615
GR  - 077012/WT_/Wellcome Trust/United Kingdom
GR  - 088340/WT_/Wellcome Trust/United Kingdom
GR  - G0500389/MRC_/Medical Research Council/United Kingdom
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070521
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - EC 3.1.3.67 (PTEN Phosphohydrolase)
SB  - IM
MH  - Animals
MH  - Chromosomal Instability/*genetics
MH  - *Chromosome Aberrations
MH  - Conserved Sequence/*genetics
MH  - Genome/genetics
MH  - Humans
MH  - Leukemia-Lymphoma, Adult T-Cell/*genetics
MH  - Lymphoma, T-Cell/*genetics
MH  - Mice
MH  - PTEN Phosphohydrolase/deficiency/genetics
MH  - Synteny/genetics
PMC - PMC2714968
MID - UKMS27310
OID - NLM: UKMS27310
EDAT- 2007/05/23 09:00
MHDA- 2007/08/01 09:00
PMCR- 2009/07/24
CRDT- 2007/05/23 09:00
PHST- 2007/03/26 00:00 [received]
PHST- 2007/04/30 00:00 [accepted]
PHST- 2007/05/23 09:00 [pubmed]
PHST- 2007/08/01 09:00 [medline]
PHST- 2007/05/23 09:00 [entrez]
PHST- 2009/07/24 00:00 [pmc-release]
AID - nature05886 [pii]
AID - 10.1038/nature05886 [doi]
PST - ppublish
SO  - Nature. 2007 Jun 21;447(7147):966-71. doi: 10.1038/nature05886. Epub 2007 May 21.