PMID- 17516154
OWN - NLM
STAT- MEDLINE
DCOM- 20071214
LR  - 20220716
IS  - 0271-9142 (Print)
IS  - 0271-9142 (Linking)
VI  - 27
IP  - 4
DP  - 2007 Jul
TI  - Involvement of MCP-1 in tubulointerstitial fibrosis through massive proteinuria 
      in anti-GBM nephritis induced in WKY rats.
PG  - 409-29
AB  - We investigated participation of monocyte chemoattractant protein-1 (MCP-1) in 
      tubulointerstitial fibrosis and correlation between MCP-1 and proteinuria in 
      Wistar-Kyoto (WKY) rats with glomerulonephritis induced by anti-glomerular 
      basement membrane (anti-GBM) antibody. WKY rats showed marked proteinuria and 
      severe glomerular crescent formation at 7 days post antibody injection. At 28 
      days, tubulointerstitial fibrotic lesions were observed, followed by sustained 
      heavy proteinuria and severe tubulointerstitial fibrosis at 56 days. Histological 
      examination revealed that the overlapped immunoreactivities of MCP-1, rat 
      albumin, and p65NF-kappaB were detected in the same tubular segments of nephritic 
      kidney, and a significant positive correlation was observed between proteinuria 
      and MCP-1 expression in the tubulointerstitial fibrosis. ED-1- and CD8-positive 
      cells were also abundant, and there was a good correlation between 
      monocyte/macrophage recruitment and MCP-1 expression in the tubulointerstitial 
      area. These results suggest that MCP-1 participates in the progression of 
      tubulointerstitial fibrosis, through massive albuminuria, which is accompanied by 
      marked monocyte/macrophage recruitment.
FAU - Taniguchi, Hajime
AU  - Taniguchi H
AD  - Biomedical Research Laboratories, Daiichi Asubio Pharma Co., Ltd., Osaka, Japan.
FAU - Kojima, Ryoji
AU  - Kojima R
FAU - Sade, Hiroko
AU  - Sade H
FAU - Furuya, Mayumi
AU  - Furuya M
FAU - Inomata, Norio
AU  - Inomata N
FAU - Ito, Mikio
AU  - Ito M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070522
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (Ccl2 protein, rat)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Transforming Growth Factor beta)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Animals
MH  - Anti-Glomerular Basement Membrane Disease/chemically induced/*immunology
MH  - Chemokine CCL2/genetics/*immunology/urine
MH  - Creatinine/blood/urine
MH  - Disease Models, Animal
MH  - Disease Progression
MH  - Fibrosis/chemically induced/immunology/pathology
MH  - Gene Expression Regulation
MH  - Kidney/chemistry/*immunology/pathology
MH  - Male
MH  - Nephritis, Interstitial/chemically induced/*immunology
MH  - Proteinuria/chemically induced/*immunology/urine
MH  - Rats
MH  - Rats, Inbred Lew
MH  - Rats, Inbred WKY
MH  - Rats, Wistar
MH  - Species Specificity
MH  - Transforming Growth Factor beta/genetics/metabolism
EDAT- 2007/05/23 09:00
MHDA- 2007/12/15 09:00
CRDT- 2007/05/23 09:00
PHST- 2006/12/07 00:00 [received]
PHST- 2007/02/16 00:00 [accepted]
PHST- 2007/05/23 09:00 [pubmed]
PHST- 2007/12/15 09:00 [medline]
PHST- 2007/05/23 09:00 [entrez]
AID - 10.1007/s10875-007-9085-z [doi]
PST - ppublish
SO  - J Clin Immunol. 2007 Jul;27(4):409-29. doi: 10.1007/s10875-007-9085-z. Epub 2007 
      May 22.