PMID- 17516530
OWN - NLM
STAT- MEDLINE
DCOM- 20070807
LR  - 20221207
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 79
IP  - 7
DP  - 2007 Jul
TI  - Association between HLA-DRB1 polymorphism, high-risk HPV infection and cervical 
      neoplasia in southern Chinese.
PG  - 970-6
AB  - Multiple determinants are involved in the progression of human papillomavirus 
      (HPV)-infected cervical lesion to invasive cancer. Human leukocyte antigen (HLA) 
      polymorphism seems to play a role. This study examined the association between 
      HLA-DRB1 polymorphism, high-risk HPV infection, and the development of cervical 
      neoplasia in southern Chinese. Three hundred and seventy women with cervical 
      neoplasia (43 cervical intraepithelial neoplasia grade II, 154 grade III, and 173 
      invasive cancers) and 323 controls were recruited for HLA-DRB1 typing by a 
      sequence-based approach. Cervical specimens were collected for HPV detection by a 
      consensus primer-based polymerase chain reaction, and with the type of HPV 
      identified by hybridization with type-specific oligonucleotide probes. A 
      protective effect of HLA-DRB1*12 for cervical neoplasia was observed, and with 
      stronger associations when subgroup analyses were carried out for patients 
      infected with HPV16 and HPV58. The protective effect of HLA-DRB1*13 that had been 
      reported from other populations was not observed. The data obtained in this study 
      showed that HLA-DRB1*03 conferred a higher risk for HPV18-infected, but not for 
      HPV16-, HPV52-, or HPV58-infected cervical lesions. Although, HPV52 was reported 
      as uncommon worldwide, it was found to be the second most prevalent type in the 
      southern Chinese population. However, no additional risk association was observed 
      when subgroup analyses were performed for HPV52-infected patients. The current 
      study shows that, among southern Chinese, the outcome of HPV-infected cervical 
      lesions is associated with HLA-DRB1 polymorphism. These associations often vary 
      with the type of HPV infection.
FAU - Chan, Paul K S
AU  - Chan PK
AD  - Department of Microbiology, The Chinese University of Hong Kong, Prince of Wales 
      Hospital, Shatin, New Territories, Hong Kong Special Administrative Region, Hong 
      Kong, China. paulkschan@cuhk.edu.hk
FAU - Cheung, Tak-Hong
AU  - Cheung TH
FAU - Lin, C K
AU  - Lin CK
FAU - Siu, Shing-Shun N
AU  - Siu SS
FAU - Yim, So-Fan
AU  - Yim SF
FAU - Lo, Keith W K
AU  - Lo KW
FAU - Cheung, Jo L K
AU  - Cheung JL
FAU - Tam, Ann O Y
AU  - Tam AO
FAU - Tang, Julian W
AU  - Tang JW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Female
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DRB1 Chains
MH  - Hong Kong
MH  - Human papillomavirus 16/genetics/isolation & purification/pathogenicity
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Papillomaviridae/classification/genetics/isolation & purification/pathogenicity
MH  - Papillomavirus Infections/*genetics/*immunology/virology
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Uterine Cervical Neoplasms/*genetics/*immunology/virology
MH  - Uterine Cervical Dysplasia/genetics/immunology/virology
EDAT- 2007/05/23 09:00
MHDA- 2007/08/08 09:00
CRDT- 2007/05/23 09:00
PHST- 2007/05/23 09:00 [pubmed]
PHST- 2007/08/08 09:00 [medline]
PHST- 2007/05/23 09:00 [entrez]
AID - 10.1002/jmv.20805 [doi]
PST - ppublish
SO  - J Med Virol. 2007 Jul;79(7):970-6. doi: 10.1002/jmv.20805.