PMID- 17522017
OWN - NLM
STAT- MEDLINE
DCOM- 20070703
LR  - 20181113
IS  - 1549-5485 (Electronic)
IS  - 1072-0502 (Print)
IS  - 1072-0502 (Linking)
VI  - 14
IP  - 4
DP  - 2007 Apr
TI  - Effects of paradigm and inter-stimulus interval on age differences in eyeblink 
      classical conditioning in rabbits.
PG  - 287-94
AB  - The aim of this study was to examine parameters affecting age differences in 
      eyeblink classical conditioning in a large sample of young and middle-aged 
      rabbits. A total of 122 rabbits of mean ages of 4 or 26 mo were tested at 
      inter-stimulus intervals (ISIs) of 600 or 750 msec in the delay or trace 
      paradigms. Paradigm affected both age groups dramatically, with superior 
      performance in the delay paradigm. ISI was salient as middle-aged rabbits were 
      significantly impaired in 750-msec compared with 600-msec delays, and young 
      rabbits were significantly less impaired in 600-msec than in 750-msec trace. 
      Young rabbits performed equally well at both delay ISIs, and consequently, there 
      were significant age differences in 750-msec but not in 600-msec delays. 
      Middle-aged rabbits performed poorly at both 600- and 750-msec trace, resulting 
      in significant age differences in 600-msec but not in 750-msec trace. Timing of 
      the conditioned response has been associated with cerebellar cortical function. 
      Normal aging of the cerebellar cortex likely contributed to the magnitude of the 
      effect of ISI in delay conditioning in middle-aged rabbits. Results demonstrate 
      that the magnitude of age differences in eyeblink conditioning can be enlarged or 
      eliminated by ISI and paradigm.
FAU - Woodruff-Pak, Diana S
AU  - Woodruff-Pak DS
AD  - Department of Psychology, Temple University, Philadelphia, Pennsylvania 19122, 
      USA. pak@temple.edu
FAU - Seta, Susan E
AU  - Seta SE
FAU - Roker, LaToya A
AU  - Roker LA
FAU - Lehr, Melissa A
AU  - Lehr MA
LA  - eng
GR  - R01 AG021925/AG/NIA NIH HHS/United States
GR  - 1 R01 AG21925/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070406
PL  - United States
TA  - Learn Mem
JT  - Learning & memory (Cold Spring Harbor, N.Y.)
JID - 9435678
SB  - IM
MH  - Acoustic Stimulation
MH  - Aging/*physiology
MH  - Animals
MH  - Blinking/*physiology
MH  - Conditioning, Classical/*physiology
MH  - Female
MH  - Male
MH  - Physical Stimulation
MH  - Rabbits
MH  - Time Factors
PMC - PMC2216534
EDAT- 2007/05/25 09:00
MHDA- 2007/07/04 09:00
PMCR- 2008/04/01
CRDT- 2007/05/25 09:00
PHST- 2007/05/25 09:00 [pubmed]
PHST- 2007/07/04 09:00 [medline]
PHST- 2007/05/25 09:00 [entrez]
PHST- 2008/04/01 00:00 [pmc-release]
AID - 14/4/287 [pii]
AID - 10.1101/lm.504107 [doi]
PST - epublish
SO  - Learn Mem. 2007 Apr 6;14(4):287-94. doi: 10.1101/lm.504107. Print 2007 Apr.