PMID- 1752215
OWN - NLM
STAT- MEDLINE
DCOM- 19920127
LR  - 20180214
IS  - 0378-5866 (Print)
IS  - 0378-5866 (Linking)
VI  - 13
IP  - 3
DP  - 1991
TI  - Effects of interleukin-1 and tumor necrosis factor-alpha on astrocytes, 
      microglia, oligodendrocytes, and glial precursors in vitro.
PG  - 130-7
AB  - Microglia and astrocytes undergo proliferative and differentiative changes in 
      vivo after trauma or diseases such as multiple sclerosis (MS). Oligodendrocytes 
      are destroyed in lesions in MS. Interleukin-1 (IL1) and tumor necrosis 
      factor-alpha (TNF alpha) are involved in inflammation of the central nervous 
      system and are elevated in MS. We have investigated the changes in cell 
      morphology and cell number induced by IL1 and TNF alpha in purified and mixed 
      populations of primary rat brain microglia, astrocytes, oligodendrocytes, and 
      glial precursors. Depending on the target population, proliferation, 
      differentiation, or inhibition of cultured cells was observed. The data also 
      suggest that interactions among cell populations occur and support the hypothesis 
      that IL1 and TNF alpha effects may be indirect, possibly through induction of 
      other factors.
FAU - Merrill, J E
AU  - Merrill JE
AD  - Department of Neurology, Reed Neurological Research Center, UCLA School of 
      Medicine.
LA  - eng
GR  - R01 NS26983/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Switzerland
TA  - Dev Neurosci
JT  - Developmental neuroscience
JID - 7809375
RN  - 0 (Biomarkers)
RN  - 0 (Culture Media, Serum-Free)
RN  - 0 (Interleukin-1)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - XXE1CET956 (Indomethacin)
SB  - IM
MH  - Animals
MH  - Astrocytes/drug effects
MH  - Biomarkers
MH  - Brain/cytology
MH  - Cell Differentiation/drug effects
MH  - Cell Division/drug effects
MH  - Cells, Cultured
MH  - Culture Media, Serum-Free/pharmacology
MH  - Indomethacin/pharmacology
MH  - Interleukin-1/*pharmacology
MH  - Neuroglia/*drug effects
MH  - Oligodendroglia/drug effects
MH  - Rats
MH  - Recombinant Proteins/pharmacology
MH  - Stem Cells/drug effects
MH  - Tumor Necrosis Factor-alpha/*pharmacology
EDAT- 1991/01/01 00:00
MHDA- 1991/01/01 00:01
CRDT- 1991/01/01 00:00
PHST- 1991/01/01 00:00 [pubmed]
PHST- 1991/01/01 00:01 [medline]
PHST- 1991/01/01 00:00 [entrez]
AID - 10.1159/000112150 [doi]
PST - ppublish
SO  - Dev Neurosci. 1991;13(3):130-7. doi: 10.1159/000112150.