PMID- 17522311
OWN - NLM
STAT- MEDLINE
DCOM- 20070622
LR  - 20220309
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 27
IP  - 21
DP  - 2007 May 23
TI  - Recurrent dendrodendritic inhibition of accessory olfactory bulb mitral cells 
      requires activation of group I metabotropic glutamate receptors.
PG  - 5664-71
AB  - Metabotropic glutamate receptors (mGluRs) modulate neural excitability and 
      network tone in many brain regions. Expression of mGluRs is particularly high in 
      the accessory olfactory bulb (AOB), a CNS structure critical for detecting 
      chemicals that identify kin and conspecifics. Because of its relative simplicity 
      and its direct projection to the hypothalamus, the AOB provides a model system 
      for studying how mGluRs affect the flow of encoded sensory information to 
      downstream areas. We investigated the role of group I mGluRs in synaptic 
      processing in AOB slices and found that under control conditions, recurrent 
      inhibition of principal neurons (mitral cells) was completely eliminated by the 
      mGluR1 antagonist LY367385 [(S)-(+)-alpha-amino-4-carboxy-2 methylbenzeneacetic 
      acid]. In addition, the group I mGluR agonist DHPG 
      [(S)-3,5-dihydroxyphenylglycine; 20 microM] induced a dramatic increase in the 
      rate of spontaneous IPSCs. This increase was dependent on voltage-gated calcium 
      channels but persisted even after blockade of ionotropic glutamatergic 
      transmission and sodium channels. Together, these results indicate that mGluR1 
      plays a critical role in controlling information flow through the AOB and suggest 
      that mGluR1 may be an important locus for experience-dependent changes in 
      synaptic function.
FAU - Castro, Jason B
AU  - Castro JB
AD  - Center for Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 
      15260, USA.
FAU - Hovis, Kenneth R
AU  - Hovis KR
FAU - Urban, Nathaniel N
AU  - Urban NN
LA  - eng
GR  - F31 DC008230/DC/NIDCD NIH HHS/United States
GR  - R01 DC005798/DC/NIDCD NIH HHS/United States
GR  - R21 DC006631/DC/NIDCD NIH HHS/United States
GR  - F31 DC08230/DC/NIDCD NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Benzoates)
RN  - 0 (Receptors, Metabotropic Glutamate)
RN  - 0 (metabotropic glutamate receptor type 1)
RN  - 146669-29-6 (alpha-methyl-4-carboxyphenylglycine)
RN  - 534-82-7 (Methoxyhydroxyphenylglycol)
RN  - TE7660XO1C (Glycine)
RN  - UEH9K539KJ (3,4-dihydroxyphenylglycol)
SB  - IM
MH  - Animals
MH  - Benzoates/pharmacology
MH  - Dendrites/drug effects/*physiology
MH  - Dose-Response Relationship, Drug
MH  - Glycine/analogs & derivatives/pharmacology
MH  - Inhibitory Postsynaptic Potentials/drug effects/physiology
MH  - Methoxyhydroxyphenylglycol/analogs & derivatives/pharmacology
MH  - Mice
MH  - Neural Inhibition/drug effects/*physiology
MH  - Olfactory Bulb/drug effects/*physiology
MH  - Receptors, Metabotropic Glutamate/agonists/antagonists & inhibitors/*metabolism
MH  - Time Factors
PMC - PMC6672756
EDAT- 2007/05/25 09:00
MHDA- 2007/06/23 09:00
PMCR- 2007/11/23
CRDT- 2007/05/25 09:00
PHST- 2007/05/25 09:00 [pubmed]
PHST- 2007/06/23 09:00 [medline]
PHST- 2007/05/25 09:00 [entrez]
PHST- 2007/11/23 00:00 [pmc-release]
AID - 27/21/5664 [pii]
AID - 3223406 [pii]
AID - 10.1523/JNEUROSCI.0613-07.2007 [doi]
PST - ppublish
SO  - J Neurosci. 2007 May 23;27(21):5664-71. doi: 10.1523/JNEUROSCI.0613-07.2007.