PMID- 17523504
OWN - NLM
STAT- MEDLINE
DCOM- 20070815
LR  - 20220210
IS  - 1081-597X (Print)
IS  - 1081-597X (Linking)
VI  - 23
IP  - 5
DP  - 2007 May
TI  - Improvement of visual acuity following refractive surgery for myopia and myopic 
      anisometropia.
PG  - 447-55
AB  - PURPOSE: To test the hypothesis that anisometropic adults without significant 
      amblyopia suffer from mild visual impairment probably due to aniseikonia, which 
      might be improved by corneal refractive surgery. METHODS: Fifty-seven patients 
      presenting with myopic anisometropia > or = 3.25 diopters (D) and 174 myopic 
      controls appropriate for refractive surgery were included. Photorefractive 
      keratectomy (PRK) or LASIK was performed on 57 anisometropic eyes. As 43 of the 
      174 myopic control patients had bilateral surgery, PRK or LASIK was performed on 
      217 myopic control eyes. Best spectacle-corrected visual acuity (BSCVA), 
      refraction, and refractive correction were measured preoperatively and at 1, 3, 5 
      to 7, 8 to 13, and 25 months following surgery. RESULTS: Preoperative mean 
      spherical equivalent was -7.20 +/- 2.40 D for anisometropic patients and -6.40 
      +/- 1.90 D for myopic patients. At 8 to 13 months postoperatively, when 23 (40%) 
      anisometropic eyes and 94 (43%) myopic eyes were examined, the mean spherical 
      equivalent refractions were -0.80 +/- 1.60 D and -0.30 +/- 0.60 D, respectively. 
      Preoperatively, the mean BSCVA on a logMAR scale was -0.0143 +/- 0.0572 (Snellen 
      0.98 +/- 0.12) in the anisometropic group and 0.0136 +/- 0.0361 (Snellen 1.04 +/- 
      0.09) in the control group (P = .001). Eight to 13 months postoperatively, these 
      values were 0.0076 +/- 0.0659 (Snellen 1.03 +/- 0.15) and 0.0495 +/- 0.0692 
      (Snellen 1.13 +/- 0.18) and this difference remained statistically significant (P 
      = .012). For the myopic patients, the improvement in BSCVA reached almost maximum 
      at 3 months, and this improvement was found to be highly significant 3 months 
      after surgery (P = .001). The improvement in BSCVA was significantly slower for 
      anisometropic patients and became statistically significant only after 8 to 13 
      months postoperatively (P = .041). CONCLUSIONS: Anisometropia reduces visual 
      acuity in the more myopic eye and can be at least partially reversed by 
      refractive correction. The slower improvement in BSCVA for anisometropic patients 
      suggests plastic changes in the visual cortex following refractive surgery.
FAU - Vuori, Elisa
AU  - Vuori E
AD  - Department of Ophthalmology, University of Helsinki, Helsinki, Finland.
FAU - Tervo, Timo M T
AU  - Tervo TM
FAU - Holopainen, Martti V A
AU  - Holopainen MV
FAU - Holopainen, Juha M
AU  - Holopainen JM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Refract Surg
JT  - Journal of refractive surgery (Thorofare, N.J. : 1995)
JID - 9505927
SB  - IM
MH  - Adult
MH  - Anisometropia/*complications/physiopathology/*surgery
MH  - Eyeglasses
MH  - Female
MH  - Humans
MH  - *Keratomileusis, Laser In Situ
MH  - Lasers, Excimer
MH  - Male
MH  - Middle Aged
MH  - Myopia/*complications/physiopathology/*surgery
MH  - *Photorefractive Keratectomy
MH  - Postoperative Period
MH  - Refraction, Ocular
MH  - Time Factors
MH  - Treatment Outcome
MH  - Visual Acuity
EDAT- 2007/05/26 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/05/26 09:00
PHST- 2007/05/26 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/05/26 09:00 [entrez]
AID - 10.3928/1081-597X-20070501-05 [doi]
PST - ppublish
SO  - J Refract Surg. 2007 May;23(5):447-55. doi: 10.3928/1081-597X-20070501-05.