PMID- 17523852
OWN - NLM
STAT- MEDLINE
DCOM- 20070720
LR  - 20181201
IS  - 0033-7587 (Print)
IS  - 0033-7587 (Linking)
VI  - 167
IP  - 6
DP  - 2007 Jun
TI  - Retrospective biodosimetry among United States radiologic technologists.
PG  - 727-34
AB  - Measurement of chromosome translocations in peripheral blood lymphocytes has been 
      used to quantify prior exposure to ionizing radiation, including for workers 
      exposed to low, chronic doses. We assessed translocation frequencies in a subset 
      of U.S. radiologic technologists to substantiate ionizing radiation dose 
      estimates developed for 110,418 technologists who worked between 1916 and 1984. 
      From 3,441 cohort members known to have begun working before 1950, we selected a 
      sample of 152, stratified by estimated cumulative dose, over-sampling from 
      higher-dose categories and excluding persons with a prior cancer diagnosis, a 
      personal or family history of chromosomal instability disorders, or a current 
      history of smoking. Estimates of film-badge dose ranged from less than 10 cSv to 
      more than 30 cSv. Blood samples, obtained in 2004, were analyzed by fluorescence 
      in situ hybridization (FISH) whole chromosome painting by simultaneously labeling 
      chromosomes 1, 2 and 4 in red and 3, 5 and 6 in green. Translocations were scored 
      in 1800 well-spread metaphase cells and expressed per 100 cell equivalents (CE) 
      per person. Linear Poisson regression models with allowance for overdispersion 
      were used to assess the relationship between estimated occupational red bone 
      marrow absorbed dose in cGy and translocation frequency, adjusted for age, gender 
      and estimated red bone marrow absorbed dose score from personal diagnostic 
      procedures. We observed 0.09 excess translocations per 100 CE per cGy red bone 
      marrow dose (95% CI: -0.01, 0.2; P = 0.07), which is similar to the expected 
      estimate based on previous cytogenetic studies (0.05 excess translocations per 
      100 CE per cGy). Despite uncertainty in the estimates of occupational red bone 
      marrow absorbed doses, we found good general agreement between the doses and 
      translocation frequencies, lending support to the credibility of the dose 
      assessment for this large cohort of U.S. radiologic technologists.
FAU - Bhatti, Parveen
AU  - Bhatti P
AD  - Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, 
      National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
FAU - Preston, Dale L
AU  - Preston DL
FAU - Doody, Michele Morin
AU  - Doody MM
FAU - Hauptmann, Michael
AU  - Hauptmann M
FAU - Kampa, Diane
AU  - Kampa D
FAU - Alexander, Bruce H
AU  - Alexander BH
FAU - Petibone, Dayton
AU  - Petibone D
FAU - Simon, Steven L
AU  - Simon SL
FAU - Weinstock, Robert M
AU  - Weinstock RM
FAU - Bouville, Andre
AU  - Bouville A
FAU - Yong, Lee C
AU  - Yong LC
FAU - Freedman, D Michal
AU  - Freedman DM
FAU - Mabuchi, Kiyohiko
AU  - Mabuchi K
FAU - Linet, Martha S
AU  - Linet MS
FAU - Edwards, Alan A
AU  - Edwards AA
FAU - Tucker, James D
AU  - Tucker JD
FAU - Sigurdson, Alice J
AU  - Sigurdson AJ
LA  - eng
GR  - N01 CP31018/CP/NCI NIH HHS/United States
GR  - N02 CP31003/CP/NCI NIH HHS/United States
GR  - N02 CP31013/CP/NCI NIH HHS/United States
GR  - Y1 CP9012/CP/NCI NIH HHS/United States
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Radiat Res
JT  - Radiation research
JID - 0401245
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Allied Health Personnel/*statistics & numerical data
MH  - Biological Assay/methods/*statistics & numerical data
MH  - Body Burden
MH  - Female
MH  - Humans
MH  - Male
MH  - Occupational Exposure/*analysis/*statistics & numerical data
MH  - Radiation Dosage
MH  - Radiometry/*statistics & numerical data
MH  - Relative Biological Effectiveness
MH  - Retrospective Studies
MH  - Risk Assessment/methods
MH  - Risk Factors
MH  - *Technology, Radiologic/statistics & numerical data
MH  - Translocation, Genetic/genetics/*radiation effects
MH  - United States/epidemiology
MH  - Workforce
EDAT- 2007/05/26 09:00
MHDA- 2007/07/21 09:00
CRDT- 2007/05/26 09:00
PHST- 2006/11/27 00:00 [received]
PHST- 2007/01/31 00:00 [accepted]
PHST- 2007/05/26 09:00 [pubmed]
PHST- 2007/07/21 09:00 [medline]
PHST- 2007/05/26 09:00 [entrez]
AID - RR0894 [pii]
AID - 10.1667/RR0894.1 [doi]
PST - ppublish
SO  - Radiat Res. 2007 Jun;167(6):727-34. doi: 10.1667/RR0894.1.