PMID- 17524360
OWN - NLM
STAT- MEDLINE
DCOM- 20070809
LR  - 20081121
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 358
IP  - 4
DP  - 2007 Jul 13
TI  - BDNF induction with mild exercise in the rat hippocampus.
PG  - 961-7
AB  - Although chronic voluntary physical activity has been shown to enhance 
      hippocampal brain-derived neurotrophic factor (BDNF) expression in animals, the 
      effects of forced exercise on a treadmill have not been fully investigated. We 
      assessed induction of c-fos and BDNF expression with acute exercise at different 
      running intensities. The mRNA for c-fos, a marker for neuronal activation, was 
      up-regulated even under low-intensity running (15 m/min), although its induction 
      appeared to be intensity dependent. On the other hand, increases in BDNF mRNA and 
      protein were seen only at low-intensity running. At moderate-intensity running 
      (25 m/min) which elevated blood lactate and corticosterone levels, induction of 
      BDNF mRNA, but not its protein, was even depressed. Our study shows the first 
      evidence that with an acute low-intensity exercise that is minimally stressful, 
      hippocampal activation and BDNF expression can be achieved lending support to the 
      idea that mild exercise could yield to greater benefits in hippocampal functions 
      compared to the more strenuous forms.
FAU - Soya, Hideaki
AU  - Soya H
AD  - Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of 
      Comprehensive Human Sciences, 1-1-1 Tennoudai, Tsukuba 305-8574, Japan. 
      hsoya@taiiku.tsukuba.ac.jp
FAU - Nakamura, Toru
AU  - Nakamura T
FAU - Deocaris, Custer C
AU  - Deocaris CC
FAU - Kimpara, Akiyo
AU  - Kimpara A
FAU - Iimura, Miho
AU  - Iimura M
FAU - Fujikawa, Takahiko
AU  - Fujikawa T
FAU - Chang, Hyukki
AU  - Chang H
FAU - McEwen, Bruce S
AU  - McEwen BS
FAU - Nishijima, Takeshi
AU  - Nishijima T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070507
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Hippocampus/*metabolism
MH  - Male
MH  - Physical Conditioning, Animal/*methods
MH  - Physical Exertion/*physiology
MH  - Rats
MH  - Rats, Wistar
MH  - Running/*physiology
EDAT- 2007/05/26 09:00
MHDA- 2007/08/10 09:00
CRDT- 2007/05/26 09:00
PHST- 2007/04/12 00:00 [received]
PHST- 2007/04/18 00:00 [accepted]
PHST- 2007/05/26 09:00 [pubmed]
PHST- 2007/08/10 09:00 [medline]
PHST- 2007/05/26 09:00 [entrez]
AID - S0006-291X(07)00856-X [pii]
AID - 10.1016/j.bbrc.2007.04.173 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2007 Jul 13;358(4):961-7. doi: 
      10.1016/j.bbrc.2007.04.173. Epub 2007 May 7.