PMID- 17524508
OWN - NLM
STAT- MEDLINE
DCOM- 20071210
LR  - 20131121
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 58
IP  - 4
DP  - 2007 Aug
TI  - Threshold-like pattern of neuronal activation in the hypothalamus during 
      treadmill running: establishment of a minimum running stress (MRS) rat model.
PG  - 341-8
AB  - Despite the indication that the hypothalamo-pituitary-adrenal (HPA) axis is 
      activated during treadmill running, there have not been any studies focusing on 
      the relationship between exercise intensity and region-specific neural activities 
      in hypothalamus. To address this, rats were subjected to 30 min of running, 
      either at middle (supra-LT, 25 m min(-1)) or low speeds (sub-LT, 15 m min(-1)), 
      and c-Fos-(+) cells were counted and compared with control rats. Significant 
      increases in blood glucose and lactate levels, and plasma ACTH and osmolality 
      levels were observed during supra-LT running. Only supra-LT running significantly 
      increased c-Fos induction in various hypothalamic regions, namely, the medial 
      preoptic area (MPO), periventricular nucleus (Pe), suprachiasmatic nucleus (SCN), 
      supraoptic nucleus (SON), parvocellular division of the paraventricular nucleus 
      (pPVN), anterior hypothalamic area (AH), arcuate nucleus (ARC) and posterior 
      hypothalamic nucleus (PH). However, sub-LT caused no effect on c-Fos 
      accumulation. This indicates that the hypothalamus responds uniquely to running 
      in a threshold-like pattern distinct from the speed-dependent pattern previously 
      reported for the medulla oblongata [Ohiwa et al., 2006a,b]. In addition, these 
      results showed a physiologic basis for mild exercise useful for establishing our 
      minimum running stress (MRS) rat model, or the running conditions that minimize 
      the activation of the HPA axis.
FAU - Soya, Hideaki
AU  - Soya H
AD  - Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of 
      Comprehensive Human Sciences, Tsukuba 305-8574, Japan. hsoya@taiiku.tsukuba.ac.jp
FAU - Mukai, Akira
AU  - Mukai A
FAU - Deocaris, Custer C
AU  - Deocaris CC
FAU - Ohiwa, Nao
AU  - Ohiwa N
FAU - Chang, Hyukki
AU  - Chang H
FAU - Nishijima, Takeshi
AU  - Nishijima T
FAU - Fujikawa, Takahiko
AU  - Fujikawa T
FAU - Togashi, Kenji
AU  - Togashi K
FAU - Saito, Tsuyoshi
AU  - Saito T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070413
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (Blood Glucose)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 33X04XA5AT (Lactic Acid)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Behavior, Animal
MH  - Blood Glucose/metabolism
MH  - Disease Models, Animal
MH  - Hypothalamus/*pathology
MH  - Immunohistochemistry/methods
MH  - Lactic Acid/blood/*metabolism
MH  - Male
MH  - Neurons/*metabolism
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - *Running
MH  - Stress, Psychological/*metabolism/*pathology
MH  - Time Factors
EDAT- 2007/05/26 09:00
MHDA- 2007/12/11 09:00
CRDT- 2007/05/26 09:00
PHST- 2007/03/06 00:00 [received]
PHST- 2007/04/04 00:00 [revised]
PHST- 2007/04/06 00:00 [accepted]
PHST- 2007/05/26 09:00 [pubmed]
PHST- 2007/12/11 09:00 [medline]
PHST- 2007/05/26 09:00 [entrez]
AID - S0168-0102(07)00128-9 [pii]
AID - 10.1016/j.neures.2007.04.004 [doi]
PST - ppublish
SO  - Neurosci Res. 2007 Aug;58(4):341-8. doi: 10.1016/j.neures.2007.04.004. Epub 2007 
      Apr 13.