PMID- 17524862
OWN - NLM
STAT- MEDLINE
DCOM- 20071026
LR  - 20151119
IS  - 0041-1345 (Print)
IS  - 0041-1345 (Linking)
VI  - 39
IP  - 4
DP  - 2007 May
TI  - Serum T-lymphocyte cytokines cannot predict early acute rejection in renal 
      transplantation.
PG  - 958-61
AB  - Despite numerous studies, the precise role of Th1/Th2 cytokines in acute renal 
      allograft rejection remains unclear. To provide insight into the role of 
      cytokines in acute allograft rejection, we measured serum T-cell cytokine 
      concentrations for correlation with clinical events after renal transplantation 
      in adults. Serum Th1 (interleukin-2 [IL-2] and interferon-gamma [IFN gamma] and 
      Th2 (IL-4, IL-10) cytokine concentrations were measured in 60 consecutive living 
      donor kidney transplant recipients namely, 40 males, overall mean age 38.82 
      years), on the day before as well as 7 and 14 days posttransplantation using 
      ELISA. Patients were stratified based upon acute rejection episode (ARE) in the 
      first month after transplantation. Immunosuppression consisted of cyclosporine, 
      mycophenolate mofetil, and prednisolone. ARE was diagnosed based on an increased 
      plasma creatinine of more than 50%, sonographic analysis, radioisotope scan, 
      pathologic findings, or measured cyclosporine blood levels. Twelve ARE were 
      diagnosed among patients (20%). There was no significant difference between the 2 
      groups with respect to the mean serum concentration values of IL-2, IL-10, IL-4, 
      and IFN gamma on the day before or 7 or 14 days after transplantation. This study 
      showed that there was no correlation between the Th1/Th2 serum cytokine profiles 
      and early ARE in living donor kidney transplantation.
FAU - Ghafari, A
AU  - Ghafari A
AD  - Department of Internal Medicine, Urmia University of Medical Sciences, Urmia, 
      Iran. ghaf_ali@yahoo.com
FAU - Makhdoomi, K
AU  - Makhdoomi K
FAU - Ahmadpour, P
AU  - Ahmadpour P
FAU - Afshari, A T
AU  - Afshari AT
FAU - Lak, S S
AU  - Lak SS
FAU - Fakhri, L
AU  - Fakhri L
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Transplant Proc
JT  - Transplantation proceedings
JID - 0243532
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-2)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Cytokines/*blood
MH  - Female
MH  - Graft Rejection/*epidemiology
MH  - Humans
MH  - Interferon-gamma/blood
MH  - Interleukin-2/blood
MH  - Kidney Transplantation/*immunology
MH  - Living Donors
MH  - Male
MH  - Predictive Value of Tests
MH  - T-Lymphocytes/*physiology
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
EDAT- 2007/05/26 09:00
MHDA- 2007/10/30 09:00
CRDT- 2007/05/26 09:00
PHST- 2007/05/26 09:00 [pubmed]
PHST- 2007/10/30 09:00 [medline]
PHST- 2007/05/26 09:00 [entrez]
AID - S0041-1345(07)00276-X [pii]
AID - 10.1016/j.transproceed.2007.03.015 [doi]
PST - ppublish
SO  - Transplant Proc. 2007 May;39(4):958-61. doi: 10.1016/j.transproceed.2007.03.015.