PMID- 17526165
OWN - NLM
STAT- MEDLINE
DCOM- 20081210
LR  - 20171116
IS  - 1003-5370 (Print)
IS  - 1003-5370 (Linking)
VI  - 27
IP  - 4
DP  - 2007 Apr
TI  - [Effect of spleen-invigorating prescription on dendritic cell function in 
      patients with chronic hepatitis B of TCM Pi-deficiency syndrome type].
PG  - 300-2
AB  - OBJECTIVE: To observe the effect of Spleen-invigorating Prescription (SIP) on 
      dendritic cell function in patients with chronic hepatitis B. METHODS: A total of 
      60 patients with chronic HBV of Pi-deficiency syndrome type were enrolled and 
      randomized to 2 groups, 30 in each group. Patients in the control group were 
      given intramuscular injection with human interferon alpha 1b, 3 times a week, 
      while those in the treated group were given orally with SIP twice a day, the 
      therapy lasted for 6 months. Dendritic cells (DCs) were isolated from peripheral 
      blood and cultured, then the expression of surface markers, HLA-DR, CD86, CD80, 
      CD40, CD14 and CD11c were detected before and after treatment by flow cytometry, 
      and the function of DCs was also evaluated by mixed lymphocyte reaction (MLR) 
      determination once before treatment and once after treatment. RESULTS: The 
      expressions of DCs' surface CD86, CD80, CD40 and CD11c in the treated group were 
      higher (P < 0.05, P < 0.01) and the changes of stimulating index, IFN-gamma and 
      IL-12 were superior in the treated group to those in the control group (P < 
      0.05). CONCLUSIONS: SIP can significantly improve DC's function, so, one of 
      mechanisms of SIP in improving clinical efficacy may be the regulation of immune 
      function.
FAU - Gao, Yue-qiu
AU  - Gao YQ
AD  - Affiliated Shuguang Hospital, Shanghai University of TCM, Shanghai. 
      gaoyueqiu@hotmail.com
FAU - Zheng, Ya-jiang
AU  - Zheng YJ
FAU - Wang, Ling-tai
AU  - Wang LT
LA  - chi
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhongguo Zhong Xi Yi Jie He Za Zhi
JT  - Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese 
      journal of integrated traditional and Western medicine
JID - 9211576
RN  - 0 (Antiviral Agents)
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-2 Antigen)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Interferon-alpha)
SB  - IM
MH  - Adult
MH  - Antiviral Agents/therapeutic use
MH  - B7-1 Antigen/analysis
MH  - B7-2 Antigen/analysis
MH  - Dendritic Cells/cytology/*drug effects/immunology
MH  - Diagnosis, Differential
MH  - Drugs, Chinese Herbal/*therapeutic use
MH  - Female
MH  - Hepatitis B, Chronic/*drug therapy/immunology
MH  - Humans
MH  - Interferon-alpha/*therapeutic use
MH  - Male
MH  - Medicine, Chinese Traditional
MH  - Middle Aged
MH  - Phytotherapy
MH  - Syndrome
MH  - Yang Deficiency/drug therapy
MH  - Young Adult
EDAT- 2007/05/29 09:00
MHDA- 2008/12/17 09:00
CRDT- 2007/05/29 09:00
PHST- 2007/05/29 09:00 [pubmed]
PHST- 2008/12/17 09:00 [medline]
PHST- 2007/05/29 09:00 [entrez]
PST - ppublish
SO  - Zhongguo Zhong Xi Yi Jie He Za Zhi. 2007 Apr;27(4):300-2.