PMID- 17526943
OWN - NLM
STAT- MEDLINE
DCOM- 20070918
LR  - 20221207
IS  - 1355-008X (Print)
IS  - 1355-008X (Linking)
VI  - 30
IP  - 3
DP  - 2006 Dec
TI  - LOH on chromosome 11q, but not SDHD and Men1 mutations was frequently detectable 
      in Chinese patients with pheochromocytoma and paraganglioma.
PG  - 307-12
AB  - Recently, the succinate dehydrogenase subunit D (SDHD) gene has been reported as 
      one of the major susceptibility genes for pheochromocytoma (PCC) and 
      paraganglioma (PGL). In addition, loss of heterozygosity (LOH) on chromosome 11, 
      mainly in 11q23 and 11q13, is observed frequently in PGL. Based on the fact that 
      mutation frequency of the SDHD gene is less than that of allelic loss at 
      chromosome11q, where the SDHD gene is located, this region may contain other 
      candidate tumor-suppressor genes involved in pathogenesis of PCC/PGL. The 
      tumor-suppressor gene Men1 located in 11q13 is responsible for multiple endocrine 
      neoplasia type 1 (Men1). However, the involvement of the Men1 gene in 
      tumorigenesis of sporadic PCC/PGL is yet to be determined. To understand the 
      roles of the two tumor-suppressor genes and LOH on chromosome 11q in Chinese 
      patients with sporadic PCC or PGL, we performed mutation detection of the SDHD 
      and Men1 genes in tumors from 35 Chinese patients with PCC/PGL; we also did LOH 
      analysis at chromosome 11q for 25 patients out of the 35. No mutation was found 
      in all of 35 patients. However, LOH was detected at one or more loci in 11 of the 
      25 (44%) tumor samples. The highest frequency of LOH occurred at D11S2006 (41%). 
      Our results suggested that mutation in SDHD or Men1 gene was not found in Chinese 
      patients with sporadic PCC/PGL. However the loss of chromosome 11q might be 
      critical in development of PCC or PGL.
FAU - Sun, Hai-Yan
AU  - Sun HY
AD  - Shanghai Clinical Center for Endocrine and Metabolic Diseass, Ruijin Hospital, 
      Shanghai JiaoTong University Medical School, Shanghai 200025, P.R. China.
FAU - Cui, Bin
AU  - Cui B
FAU - Su, Din-Wei
AU  - Su DW
FAU - Jin, Xiao-Long
AU  - Jin XL
FAU - Sun, Fu-Kang
AU  - Sun FK
FAU - Zu, Yu
AU  - Zu Y
FAU - Jiang, Lei
AU  - Jiang L
FAU - Wang, Wei-Qing
AU  - Wang WQ
FAU - Ning, Guang
AU  - Ning G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (SDHD protein, human)
RN  - EC 1.3.99.1 (Succinate Dehydrogenase)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - China
MH  - *Chromosomes, Human, Pair 11
MH  - DNA Mutational Analysis
MH  - Female
MH  - Humans
MH  - *Loss of Heterozygosity
MH  - Male
MH  - Middle Aged
MH  - Pheochromocytoma/*genetics
MH  - Proto-Oncogene Proteins/*genetics
MH  - Succinate Dehydrogenase/*genetics
EDAT- 2007/05/29 09:00
MHDA- 2007/09/19 09:00
CRDT- 2007/05/29 09:00
PHST- 2006/10/23 00:00 [received]
PHST- 2006/12/20 00:00 [revised]
PHST- 2006/12/22 00:00 [accepted]
PHST- 2007/05/29 09:00 [pubmed]
PHST- 2007/09/19 09:00 [medline]
PHST- 2007/05/29 09:00 [entrez]
AID - ENDO:30:3:307 [pii]
AID - 10.1007/s12020-006-0009-0 [doi]
PST - ppublish
SO  - Endocrine. 2006 Dec;30(3):307-12. doi: 10.1007/s12020-006-0009-0.