PMID- 17530001
OWN - NLM
STAT- MEDLINE
DCOM- 20071227
LR  - 20221207
IS  - 0268-3369 (Print)
IS  - 0268-3369 (Linking)
VI  - 40
IP  - 3
DP  - 2007 Aug
TI  - Indiscernible benefit of high-resolution HLA typing in improving long-term 
      clinical outcome of unrelated umbilical cord blood transplant.
PG  - 201-8
AB  - The success of allogeneic hematopoietic stem cell transplantation depends in part 
      on the accuracy of human leukocyte antigen (HLA) matching between the 
      donor-recipient pair. The higher the number of matching HLA alleles, the smaller 
      the chance that the transplant recipient will develop complications. Umbilical 
      cord blood (UCB) transplantation was noted to result in a remarkably low 
      frequency and severity of graft-versus-host disease (GvHD) and graft rejection 
      compared to that in unrelated bone marrow transplant recipients. At present most 
      banks match UCB donors for respective recipients by HLA-A, -B low-resolution 
      typing and -DRB1 high-resolution typing. We retrospectively conducted 
      high-resolution sequence-based HLA typing on DNA samples available from 65 
      Chinese UCB-recipient pairs typed previously by using low-resolution 
      sequence-specific oligonucleotide probes and sequence-specific primers, and 
      evaluated the clinical outcome. High-resolution typing revealed imperceptible HLA 
      alleles that were hardly identified in low-resolution typing. Univariate analyses 
      demonstrated no significant correlation between the extents of high-resolution 
      HLA disparity with engraftment, graft failure, acute GvHD, transplant-related 
      mortality and long-term 6-year overall survival. Data from the study suggest that 
      high-resolution typing for HLA-A, -B and -DRB1 contributed no substantial 
      improvement to UCB transplant outcome. Low-resolution typing appears to be 
      amenable to matching UCB-recipient pairs without compromising the quality of 
      transplant.
FAU - Liao, C
AU  - Liao C
AD  - Guangzhou Cord Blood Bank, Guangzhou Medical College, Guangzhou Maternal and 
      Neonatal Hospital, Guangzhou, China. canliao@hotmail.com
FAU - Wu, J Y
AU  - Wu JY
FAU - Xu, Z P
AU  - Xu ZP
FAU - Li, Y
AU  - Li Y
FAU - Yang, X
AU  - Yang X
FAU - Chen, J S
AU  - Chen JS
FAU - Tang, X W
AU  - Tang XW
FAU - Gu, S L
AU  - Gu SL
FAU - Huang, Y N
AU  - Huang YN
FAU - Tang, P H
AU  - Tang PH
FAU - Tsang, K S
AU  - Tsang KS
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20070528
PL  - England
TA  - Bone Marrow Transplant
JT  - Bone marrow transplantation
JID - 8702459
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People
MH  - Bone Marrow Transplantation
MH  - Child
MH  - Child, Preschool
MH  - China
MH  - Cord Blood Stem Cell Transplantation/*mortality
MH  - Female
MH  - Follow-Up Studies
MH  - Graft Rejection/genetics/*mortality
MH  - Graft vs Host Disease/genetics/*mortality
MH  - *HLA Antigens/genetics
MH  - Hematologic Diseases/genetics/mortality/therapy
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Infant
MH  - Male
MH  - Metabolic Diseases/genetics/mortality/therapy
MH  - Retrospective Studies
MH  - Sequence Analysis, DNA
MH  - Survival Rate
EDAT- 2007/05/29 09:00
MHDA- 2007/12/28 09:00
CRDT- 2007/05/29 09:00
PHST- 2007/05/29 09:00 [pubmed]
PHST- 2007/12/28 09:00 [medline]
PHST- 2007/05/29 09:00 [entrez]
AID - 1705711 [pii]
AID - 10.1038/sj.bmt.1705711 [doi]
PST - ppublish
SO  - Bone Marrow Transplant. 2007 Aug;40(3):201-8. doi: 10.1038/sj.bmt.1705711. Epub 
      2007 May 28.