PMID- 17530308
OWN - NLM
STAT- MEDLINE
DCOM- 20070730
LR  - 20220716
IS  - 0344-5607 (Print)
IS  - 0344-5607 (Linking)
VI  - 30
IP  - 3
DP  - 2007 Jul
TI  - BDNF contributes to animal model neuropathic pain after peripheral nerve 
      transection.
PG  - 235-43; discussion 243
AB  - The outcome of peripheral nerve injury is often impaired by neuropathic pain, 
      which is resistant to most analgesics and presents a serious clinical problem. 
      The mechanisms underlying post-traumatic neuropathic pain remain unclear, but 
      they are likely associated with the regeneration processes. Brain-derived 
      neurotrophic factor (BDNF) is known to enhance peripheral nerve regeneration and 
      is also considered to be an endogenous modulator of nociceptive responses 
      following spinal cord lesion. The aim of this work was to examine the local 
      effect of BDNF in a neuropathic pain model. Sciatic nerves of adult male rats 
      were transected and supplied with connective tissue chambers filled with (1) 
      fibrin only, (2) fibrin with BDNF, or (3) fibrin with antibodies against BDNF. In 
      control animals the nerve was transected and no chamber was applied. During 
      follow-up, autotomy behavior was assessed. Seven weeks after the operation, the 
      number of surviving and regenerating neurons in dorsal root ganglia was counted 
      and the neuroma incidence was examined. We found that local inactivation of BDNF 
      decreased the incidence as well as severity of autotomy and neuroma formation, 
      but did not influence neuron regeneration into the chambers. These results 
      indicate that BDNF plays a locally crucial role in neuropathic pain development 
      after peripheral nerve injury.
FAU - Marcol, Wieslaw
AU  - Marcol W
AD  - Department of Physiology, Medical University of Silesia, 18 Medykow St., 40-752, 
      Katowice, Poland. Vie@alpha.net.pl
FAU - Kotulska, Katarzyna
AU  - Kotulska K
FAU - Larysz-Brysz, Magdalena
AU  - Larysz-Brysz M
FAU - Kowalik, Joanna Lewin
AU  - Kowalik JL
LA  - eng
PT  - Journal Article
DEP - 20070526
PL  - Germany
TA  - Neurosurg Rev
JT  - Neurosurgical review
JID - 7908181
RN  - 0 (Antibodies, Blocking)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 9001-31-4 (Fibrin)
RN  - 9001-32-5 (Fibrinogen)
RN  - EC 3.4.21.5 (Thrombin)
SB  - IM
MH  - Amputation, Traumatic/pathology
MH  - Animals
MH  - Antibodies, Blocking/pharmacology
MH  - Behavior, Animal/physiology
MH  - Brain-Derived Neurotrophic Factor/antagonists & inhibitors/*pharmacology
MH  - Fibrin/pharmacology
MH  - Fibrinogen/pharmacology
MH  - Ganglia, Spinal/injuries
MH  - Male
MH  - Nerve Regeneration/drug effects
MH  - Neuroma/pathology
MH  - Neurons/drug effects/physiology
MH  - Pain/*physiopathology/psychology
MH  - Peripheral Nervous System Diseases/*physiopathology/psychology
MH  - Peripheral Nervous System Neoplasms/pathology
MH  - Rats
MH  - Rats, Wistar
MH  - Sciatic Neuropathy/physiopathology
MH  - Thrombin/therapeutic use
EDAT- 2007/05/29 09:00
MHDA- 2007/07/31 09:00
CRDT- 2007/05/29 09:00
PHST- 2006/12/28 00:00 [received]
PHST- 2007/03/04 00:00 [accepted]
PHST- 2007/05/29 09:00 [pubmed]
PHST- 2007/07/31 09:00 [medline]
PHST- 2007/05/29 09:00 [entrez]
AID - 10.1007/s10143-007-0085-5 [doi]
PST - ppublish
SO  - Neurosurg Rev. 2007 Jul;30(3):235-43; discussion 243. doi: 
      10.1007/s10143-007-0085-5. Epub 2007 May 26.