PMID- 17530713
OWN - NLM
STAT- MEDLINE
DCOM- 20070720
LR  - 20220408
IS  - 0004-3591 (Print)
IS  - 0004-3591 (Linking)
VI  - 56
IP  - 6
DP  - 2007 Jun
TI  - Serum matrix metalloproteinase 3 is an independent predictor of structural damage 
      progression in patients with ankylosing spondylitis.
PG  - 1846-53
AB  - OBJECTIVE: In prospective studies, only baseline radiographic damage has been 
      identified as an independent predictor of radiographic progression in ankylosing 
      spondylitis (AS). Several biomarkers have been identified as independent 
      predictors of radiographic progression in rheumatoid arthritis, however, and 
      these may be of use in AS. This study was undertaken to analyze serologic 
      biomarkers as predictors of radiographic progression in AS. METHODS: We measured 
      a panel of biomarkers reflecting cartilage turnover and osteoclasis. These 
      biomarkers were cartilage oligomeric matrix protein, human cartilage gp-39 
      (YKL-40), type II collagen epitopes detected by the C2C and C1,2C degradation 
      assays and the CPII synthesis assay, aggrecan 846 epitope, osteoprotegerin, and 
      matrix metalloproteinase 3 (MMP-3). The analysis was performed in a cohort of AS 
      patients from the Netherlands, Belgium, and France enrolled in a longitudinal 
      study, the Outcome Assessments in Ankylosing Spondylitis International Study. We 
      examined 2-year radiographic progression data scored using the modified Stoke AS 
      Spine Score (mSASSS). RESULTS: Complete data were available on 97 patients. Only 
      the biomarkers YKL-40 and MMP-3 showed weak to moderate univariate correlation 
      with 2-year progression. After adjustment for sex, age, disease duration, 
      C-reactive protein level, and baseline mSASSS, only MMP-3 was significantly 
      associated with 2-year progression (beta = 0.29, P = 0.004). Logistic regression 
      analysis revealed MMP-3 (cutoff 68 ng/ml; odds ratio 9.4 [95% confidence interval 
      1.6-56]) and baseline mSASSS (cutoff 10 mSASSS units; odds ratio 18.6 [95% 
      confidence interval 2.5-138]) as the only independent predictors of 2-year 
      progression (cutoff 3 mSASSS units; model R(2) = 50%). MMP-3 was primarily 
      contributory in patients who already had substantial baseline damage (>10 mSASSS 
      units). CONCLUSION: These results indicate that MMP-3 is a significant 
      independent predictor of radiographic progression in patients with AS, 
      particularly in those with preexisting radiographic damage.
FAU - Maksymowych, Walter P
AU  - Maksymowych WP
AD  - University of Alberta, Edmonton, Alberta, Canada. walter.maksymowych@ualberta.ca
FAU - Landewe, Robert
AU  - Landewe R
FAU - Conner-Spady, Barbara
AU  - Conner-Spady B
FAU - Dougados, Maxime
AU  - Dougados M
FAU - Mielants, Herman
AU  - Mielants H
FAU - van der Tempel, Hille
AU  - van der Tempel H
FAU - Poole, A Robin
AU  - Poole AR
FAU - Wang, Nandi
AU  - Wang N
FAU - van der Heijde, Desiree
AU  - van der Heijde D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arthritis Rheum
JT  - Arthritis and rheumatism
JID - 0370605
RN  - 0 (Biomarkers)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Cartilage/metabolism
MH  - Cohort Studies
MH  - Disease Progression
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Longitudinal Studies
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood
MH  - Middle Aged
MH  - Osteoclasts/metabolism
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Radiography
MH  - Severity of Illness Index
MH  - Spine/diagnostic imaging/*pathology
MH  - Spondylitis, Ankylosing/*blood/*pathology
EDAT- 2007/05/29 09:00
MHDA- 2007/07/21 09:00
CRDT- 2007/05/29 09:00
PHST- 2007/05/29 09:00 [pubmed]
PHST- 2007/07/21 09:00 [medline]
PHST- 2007/05/29 09:00 [entrez]
AID - 10.1002/art.22589 [doi]
PST - ppublish
SO  - Arthritis Rheum. 2007 Jun;56(6):1846-53. doi: 10.1002/art.22589.