PMID- 17531012
OWN - NLM
STAT- MEDLINE
DCOM- 20070713
LR  - 20070528
IS  - 0002-9270 (Print)
IS  - 0002-9270 (Linking)
VI  - 102
IP  - 6
DP  - 2007 Jun
TI  - Hepatitis C viremia increases the association with type 2 diabetes mellitus in a 
      hepatitis B and C endemic area: an epidemiological link with virological 
      implication.
PG  - 1237-43
AB  - OBJECTIVES: There is growing evidence with regard to the association between 
      hepatitis C virus (HCV) infection and type 2 diabetes mellitus (T2DM). However, 
      the mutual link and related virological implication have not been fully 
      clarified. The impact of hepatitis B virus (HBV) infection on the epidemiological 
      link remains unclear. This study aimed to elucidate the link between T2DM and 
      viral hepatitis infections, especially HCV infection. It also aimed to analyze 
      the associated virological characteristics and implication. METHODS: 
      Cross-sectional analysis of a computer-sampling survey among 10,975 participants 
      (aged 40-65 yr) was performed in an area endemic for HBV and HCV infections in 
      Taiwan. Outcome measures included prevalence of T2DM among different groups of 
      viral hepatitis infection, and comparison of related biochemical and virological 
      profiles. RESULTS: Of 10,975 participants studied, 9,932 eligible participants 
      were analyzed. The prevalence of T2DM, seropositivity for HBV surface antigen 
      (HBsAg) and HCV antibodies (anti-HCV), and HCV viremia was 12.5%, 13.1%, 6.5%, 
      and 4.8%, respectively. Prevalence of HCV viremia showed significant difference 
      between T2DM and non-T2DM subjects (6.9% vs 4.5%, P<0.001), whereas anti-HCV 
      seropositivity showed borderline significance (7.8% vs 6.3%, P=0.047). There was 
      no HCV genotype-specific difference between HCV genotype 1 and 2 in the 
      association with T2DM. On the other side, the prevalence of HBsAg (+) did not 
      differ between T2DM and non-T2DM subjects (12.5% vs 13.9%, P=0.19). The 
      prevalence of T2DM among HCV viremic subjects (18.0%, 86/478) was significantly 
      higher than HBsAg (+) subjects (11.4%, 155/1,363, P=0.001) and those negative for 
      both viral hepatitis markers (12.5%, 997/8,004, P=0.001). Multivariate logistic 
      regression analyses showed that HCV viremia was the leading significant factor 
      associated with T2DM, followed by male gender, hypertension, body mass index, and 
      age. CONCLUSIONS: HBV infection did not increase the association with T2DM. A 
      significant mutual link between T2DM and HCV viremia existed in this HBV/HCV 
      endemic area. There was no HCV genotype-specific difference between HCV genotype 
      1 and 2 in the association with T2DM.
FAU - Huang, Jee-Fu
AU  - Huang JF
AD  - Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, and 
      Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
FAU - Dai, Chia-Yen
AU  - Dai CY
FAU - Hwang, Shang-Jyh
AU  - Hwang SJ
FAU - Ho, Chi-Kung
AU  - Ho CK
FAU - Hsiao, Pi-Jung
AU  - Hsiao PJ
FAU - Hsieh, Ming-Yen
AU  - Hsieh MY
FAU - Lee, Li-Po
AU  - Lee LP
FAU - Lin, Zu-Yau
AU  - Lin ZY
FAU - Chen, Shinn-Chern
AU  - Chen SC
FAU - Hsieh, Ming-Yuh
AU  - Hsieh MY
FAU - Wang, Liang-Yen
AU  - Wang LY
FAU - Shin, Shyi-Jang
AU  - Shin SJ
FAU - Chang, Wen-Yu
AU  - Chang WY
FAU - Chuang, Wan-Long
AU  - Chuang WL
FAU - Yu, Ming-Lung
AU  - Yu ML
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Gastroenterol
JT  - The American journal of gastroenterology
JID - 0421030
RN  - 0 (Hepatitis B Surface Antigens)
RN  - 0 (Hepatitis C Antibodies)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Female
MH  - Hepatitis B Surface Antigens/blood
MH  - Hepatitis C Antibodies/blood
MH  - Hepatitis C, Chronic/*complications
MH  - Humans
MH  - Hypertension/complications
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Sex Factors
MH  - Viremia/*complications
EDAT- 2007/05/29 09:00
MHDA- 2007/07/14 09:00
CRDT- 2007/05/29 09:00
PHST- 2007/05/29 09:00 [pubmed]
PHST- 2007/07/14 09:00 [medline]
PHST- 2007/05/29 09:00 [entrez]
AID - AJG1181 [pii]
AID - 10.1111/j.1572-0241.2007.01181.x [doi]
PST - ppublish
SO  - Am J Gastroenterol. 2007 Jun;102(6):1237-43. doi: 
      10.1111/j.1572-0241.2007.01181.x.