PMID- 17531850
OWN - NLM
STAT- MEDLINE
DCOM- 20070802
LR  - 20220409
IS  - 0074-7742 (Print)
IS  - 0074-7742 (Linking)
VI  - 79
DP  - 2007
TI  - Multiple sclerosis in Isfahan, Iran.
PG  - 357-75
AB  - BACKGROUND: This survey was planned to study the prevalence and incidence of 
      multiple sclerosis (MS) in Isfahan, Iran and to describe the clinical features of 
      MS in general and in specific subgroups of patients (early-onset, late-onset, 
      familial, and conjugal cases) and to compare our results with other reports. 
      METHODS: A cross-sectional study was conducted from April 5, 2003 to July 31, 
      2006. All patients known to have definite MS according to McDonald's criteria, 
      alive, resident within Isfahan (a large province of Iran) and members of Isfahan 
      MS Society (IMSS) were included in the study. Demographic and case-related 
      information were recorded. A total number of 1718 definite MS patients (388 men 
      and 1330 women) were identified from IMSS database. RESULTS: The overall period 
      prevalence of MS was 43.8/100,000. Among men the prevalence was 19.2 (95% CI: 
      17.4-21.2)/100,000 and among women 69.6 (95% CI: 66-73.4)/100,000. A female 
      preponderance of 3.4 existed among these patients. In the year 2005, 143 new 
      cases were diagnosed, resulting in an incidence rate of 3.64/100,000. The mean 
      age of onset was 25.36 +/- 8.6 years (range 5-63 year), and mean duration of 
      disease was 7.1 (+/-5.2) years for men and 6.7 (+/-5) years for women. Sensory 
      and visual disturbances were the most common initial presentations with a 
      prevalence of 51.7% and 47.5%, respectively. Cases identified include: 
      early-onset MS (less than 15 years old at onset) with 87 cases (5%), late-onset 
      MS (over 50 years old at onset) with 20 cases (1.1%), familial MS with 209 cases 
      (12.2%), and conjugal MS with 6 cases (0.5%). CONCLUSION: Isfahan is a medium- to 
      high-risk area for MS, with prevalence higher than what has previously been 
      reported, possibly because of an increase in the incidence rate. Clinical and 
      demographic characteristics were similar to other reports; however, some 
      differences existed.
FAU - Saadatnia, Mohammad
AU  - Saadatnia M
AD  - Department of Neurology, Isfahan University of Medical Sciences, Isfahan 81744, 
      Iran.
FAU - Etemadifar, Masoud
AU  - Etemadifar M
FAU - Maghzi, Amir Hadi
AU  - Maghzi AH
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int Rev Neurobiol
JT  - International review of neurobiology
JID - 0374740
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Age of Onset
MH  - Aged
MH  - Aged, 80 and over
MH  - Child
MH  - Cross-Sectional Studies
MH  - Demography
MH  - Family Health
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Iran/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*epidemiology
MH  - Prevalence
MH  - Retrospective Studies
MH  - Sex Factors
EDAT- 2007/05/29 09:00
MHDA- 2007/08/03 09:00
CRDT- 2007/05/29 09:00
PHST- 2007/05/29 09:00 [pubmed]
PHST- 2007/08/03 09:00 [medline]
PHST- 2007/05/29 09:00 [entrez]
AID - S0074-7742(07)79016-5 [pii]
AID - 10.1016/S0074-7742(07)79016-5 [doi]
PST - ppublish
SO  - Int Rev Neurobiol. 2007;79:357-75. doi: 10.1016/S0074-7742(07)79016-5.