PMID- 17532064
OWN - NLM
STAT- MEDLINE
DCOM- 20080619
LR  - 20181113
IS  - 0167-4943 (Print)
IS  - 1872-6976 (Electronic)
IS  - 0167-4943 (Linking)
VI  - 46
IP  - 2
DP  - 2008 Mar-Apr
TI  - A propensity-matched study of the association of physical function and outcomes 
      in geriatric heart failure.
PG  - 161-72
AB  - Most heart failure (HF) patients are older adults. However, the association of 
      functional status and outcomes in ambulatory older adults with chronic HF has not 
      been well studied. Of the 7788 Digitalis Investigation Group (DIG) trial 
      participants, 4036 were > or =65 years. Of these, 1369 (34%) had New York Heart 
      Association (NYHA) class III-IV symptoms. We calculated propensity scores for 
      NYHA III-IV symptoms for all 4036 patients using a non-parsimonious logistic 
      regression model. We used propensity scores to match 1010 (74% of 1369) NYHA 
      III-IV patients with 1010 of NYHA I-II patients. Kaplan-Meier and matched Cox 
      proportion hazard analyses were used to estimate associations of NYHA class 
      III-IV with mortality and hospitalizations. Patients had a mean age of 73 years, 
      31% were female, and 11% were nonwhites. All-cause mortality occurred in 394 
      (rate, 1385/10000 person-years) NYHA I-II and 452 (rate, 1654/10000 person-years) 
      NYHA III-IV patients, respectively, during 2967 and 2733 years of follow up 
      (hazard ratio: HR, 1.28; 95% confidence interval CI, 1.09-1.50; p=0.002). 
      NYHA III-IV class was associated with increased cardiovascular (HR, 1.25; 95% CI, 
      1.04-1.49; p=0.016) and HF mortality (HR, 1.51; 95% CI, 1.16-1.97; p=0.002). NYHA 
      III-IV class was not significantly associated with hospitalizations due to all 
      causes (HR, 1.10; 95% CI, 0.96-1.25; p=0.165), cardiovascular causes (HR, 1.11; 
      95% CI, 0.96-1.29; p=0.150), or worsening HF (HR, 1.09, 95% CI, 0.92-1.30; 
      p=0.330). Baseline NYHA functional class was associated with mortality but not 
      with hospitalization in ambulatory older adults with chronic HF.
FAU - Ahmed, Ali
AU  - Ahmed A
AD  - University of Alabama at Birmingham, 1530 3rd Avenue South, CH-19, Ste-219, 
      Birmingham, AL 35294-2041, USA. aahmed@uab.edu
FAU - Aronow, Wilbert S
AU  - Aronow WS
LA  - eng
GR  - P50-HL077100/HL/NHLBI NIH HHS/United States
GR  - R01 HL085561/HL/NHLBI NIH HHS/United States
GR  - 1-K23-AG19211-04/AG/NIA NIH HHS/United States
GR  - K23 AG019211/AG/NIA NIH HHS/United States
GR  - P50 HL077100/HL/NHLBI NIH HHS/United States
GR  - 1-R01-HL085561-01/HL/NHLBI NIH HHS/United States
GR  - K23 AG019211-04/AG/NIA NIH HHS/United States
GR  - R01 HL085561-01/HL/NHLBI NIH HHS/United States
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20070525
PL  - Netherlands
TA  - Arch Gerontol Geriatr
JT  - Archives of gerontology and geriatrics
JID - 8214379
SB  - IM
MH  - Aged
MH  - Cause of Death/trends
MH  - Confidence Intervals
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*classification/mortality/*physiopathology
MH  - Humans
MH  - Male
MH  - Motor Activity/*physiology
MH  - Prognosis
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - *Severity of Illness Index
MH  - Stroke Volume
MH  - Survival Rate/trends
MH  - United States/epidemiology
PMC - PMC2685164
MID - NIHMS78029
EDAT- 2007/05/29 09:00
MHDA- 2008/06/20 09:00
PMCR- 2009/05/21
CRDT- 2007/05/29 09:00
PHST- 2006/11/10 00:00 [received]
PHST- 2007/03/12 00:00 [revised]
PHST- 2007/03/20 00:00 [accepted]
PHST- 2007/05/29 09:00 [pubmed]
PHST- 2008/06/20 09:00 [medline]
PHST- 2007/05/29 09:00 [entrez]
PHST- 2009/05/21 00:00 [pmc-release]
AID - S0167-4943(07)00104-5 [pii]
AID - 10.1016/j.archger.2007.03.010 [doi]
PST - ppublish
SO  - Arch Gerontol Geriatr. 2008 Mar-Apr;46(2):161-72. doi: 
      10.1016/j.archger.2007.03.010. Epub 2007 May 25.