PMID- 17532067
OWN - NLM
STAT- MEDLINE
DCOM- 20080731
LR  - 20080527
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 127
IP  - 1
DP  - 2008 Jun 23
TI  - Heart rate adjustments and analysis of recovery patterns of ST-segment depression 
      in type 2 diabetes.
PG  - 129-32
AB  - AIMS: To investigate the diagnostic value for coronary artery disease (CAD) 
      detection of evaluating time- and heart rate (HR)-related ST-segment changes (the 
      ST/HR-slope) and the post-exercise recovery pattern (the ST/HR-recovery loop) in 
      patients with type 2 diabetes mellitus (T2DM). METHODS AND RESULTS: Ninety-one 
      patients (22 female, age 59+/-9 years) with T2DM (diabetes duration 6+/-6 years) 
      performed an exercise ECG-test that was evaluated using the ST/HR slope 
      (cut-off</=-2.4 microV/bpm) and -recovery loop patterns (abnormal versus normal) 
      and compared to the conventional >/=1 mm ST-segment depression criterion and 
      dobutamine stress echo-cardiography, all evaluated against coronary angiography 
      irrespective of stress test results. Coronary angiography revealed CAD in 20 men 
      and 3 women (25%). Sensitivity for the conventional exercise test and stress 
      echocardiography was low (0.35 and 0.30), but increased significantly using the 
      ST/HR-slope (0.45), the recovery loop (0.86) or the combined ST/HR slope and 
      recovery loop criterion (0.91). The associations between angiographic 
      CAD-detection and the different tests expressed by the Odds ratio demonstrated an 
      added value of performing ST/HR analysis both over pre-test CAD risk profile and 
      the established techniques. CONCLUSION: T2DM patients capable of performing an 
      exercise test could be assessed with the ST/HR-analysis for selecting patients to 
      angiography. However, further studies including a higher number of patients are 
      needed to confirm the diagnostic value of this approach.
FAU - Johansen, Odd Erik
AU  - Johansen OE
FAU - Bjuro, Thorvald
AU  - Bjuro T
FAU - Endresen, Knut
AU  - Endresen K
FAU - Blaasaas, Karl G
AU  - Blaasaas KG
FAU - Birkeland, Kare
AU  - Birkeland K
FAU - Aakhus, Svend
AU  - Aakhus S
FAU - Gullestad, Lars
AU  - Gullestad L
LA  - eng
PT  - Letter
PT  - Research Support, Non-U.S. Gov't
DEP - 20070525
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
MH  - Analysis of Variance
MH  - Coronary Disease/*diagnosis/*physiopathology
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - Echocardiography, Stress
MH  - Electrocardiography
MH  - Exercise Test
MH  - Female
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
EDAT- 2007/05/29 09:00
MHDA- 2008/08/01 09:00
CRDT- 2007/05/29 09:00
PHST- 2007/01/08 00:00 [received]
PHST- 2007/04/01 00:00 [accepted]
PHST- 2007/05/29 09:00 [pubmed]
PHST- 2008/08/01 09:00 [medline]
PHST- 2007/05/29 09:00 [entrez]
AID - S0167-5273(07)00866-2 [pii]
AID - 10.1016/j.ijcard.2007.04.022 [doi]
PST - ppublish
SO  - Int J Cardiol. 2008 Jun 23;127(1):129-32. doi: 10.1016/j.ijcard.2007.04.022. Epub 
      2007 May 25.