PMID- 17532077 OWN - NLM STAT- MEDLINE DCOM- 20071210 LR - 20141120 IS - 0168-0102 (Print) IS - 0168-0102 (Linking) VI - 58 IP - 4 DP - 2007 Aug TI - Dorsal root ganglion regulates the transient ERK activation in the dorsal horn of the spinal cord during development. PG - 402-5 AB - In the dorsal horn of the chick embryo spinal cord, extracellular signal-regulated kinase (ERK) was phosphorylated transiently during embryonic days 6 and 9. Co-culture studies suggested that dorsal root ganglion (DRG) activated ERK in the dorsal horn. Brain-derived neurotrophic factor (BDNF) activated ERK in the dorsal horn, and anti-BDNF blocked the DRG-induced ERK activation. These results suggest roles of BDNF in the DRG-induced ERK activation in the embryonic dorsal horn. FAU - Kato, Taro AU - Kato T AD - Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan. FAU - Ohtani-Kaneko, Ritsuko AU - Ohtani-Kaneko R FAU - Shiga, Takashi AU - Shiga T LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20070429 PL - Ireland TA - Neurosci Res JT - Neuroscience research JID - 8500749 RN - 0 (Antibodies) RN - 0 (Brain-Derived Neurotrophic Factor) RN - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases) SB - IM MH - Animals MH - Antibodies/pharmacology MH - Brain-Derived Neurotrophic Factor/immunology/pharmacology MH - Chick Embryo MH - Enzyme Activation/drug effects/physiology MH - Extracellular Signal-Regulated MAP Kinases/*metabolism MH - Ganglia, Spinal/*physiology MH - In Vitro Techniques MH - *Spinal Cord/anatomy & histology/embryology/enzymology MH - Time Factors EDAT- 2007/05/29 09:00 MHDA- 2007/12/11 09:00 CRDT- 2007/05/29 09:00 PHST- 2007/03/21 00:00 [received] PHST- 2007/04/23 00:00 [revised] PHST- 2007/04/24 00:00 [accepted] PHST- 2007/05/29 09:00 [pubmed] PHST- 2007/12/11 09:00 [medline] PHST- 2007/05/29 09:00 [entrez] AID - S0168-0102(07)00153-8 [pii] AID - 10.1016/j.neures.2007.04.010 [doi] PST - ppublish SO - Neurosci Res. 2007 Aug;58(4):402-5. doi: 10.1016/j.neures.2007.04.010. Epub 2007 Apr 29.