PMID- 17532357
OWN - NLM
STAT- MEDLINE
DCOM- 20071113
LR  - 20070730
IS  - 0041-0101 (Print)
IS  - 0041-0101 (Linking)
VI  - 50
IP  - 3
DP  - 2007 Sep 1
TI  - Proteins, lethality and in vivo effects of Iurus dufoureius asiaticus scorpion 
      venom.
PG  - 394-9
AB  - Iurus dufoureius asiaticus, Birula, 1903 scorpions were collected in Mugla 
      province located in the Aegean region, Turkey. There are few number of 
      publications about I.d. asiaticus, and there are no data regarding minimal lethal 
      dose and effects of the scorpion venom till now. This is the first study about 
      toxicity and effects of I.d. asiaticus scorpion venom in mice. Previously, most 
      of the proteins in venom of I.d. asiaticus from Aydin region in Turkey were 
      reported to be between 14 and 205 kDa in size. In this study, we determined the 
      electrophoretic protein pattern of the venom taken from Mugla province to be 
      between 29 and 116 kDa by SDS-PAGE. Intracerebroventricular (i.c.v.) was 
      determined instead of s.c. injection since there were no deaths in any s.c. test 
      groups. The LD(50) of I.d. asiaticus scorpion venom was found to be 47.7 
      microg/20 g mouse by i.c.v. injection route. After s.c. injection venom, mice 
      were shown any intoxication symptoms. On the other hand, after i.c.v. 
      administration of venom, mice showed symptoms such as excitability, hyper 
      salivation, weakness, paralysis, coma and resulting in death. The possible cause 
      of death could be due to multi-system organ failure depending on the toxic effect 
      of the venom. These both results showed that the venom was not lethal on s.c. 
      injection, but it was lethal on i.c.v. injection. This may imply that the 
      scorpion is of little danger to humans.
FAU - Ozkan, Ozcan
AU  - Ozkan O
AD  - Refik Saydam Hygiene Center, Ankara 06100, Turkey. ozcanozkan_62@hotmail.com
FAU - Ciftci, Gulay
AU  - Ciftci G
FAU - Pekmezci, Gokmen Zafer
AU  - Pekmezci GZ
FAU - Kar, Sirri
AU  - Kar S
FAU - Uysal, Hamdi
AU  - Uysal H
FAU - Karaer, Kadri Zafer
AU  - Karaer KZ
LA  - eng
PT  - Journal Article
DEP - 20070427
PL  - England
TA  - Toxicon
JT  - Toxicon : official journal of the International Society on Toxinology
JID - 1307333
RN  - 0 (Proteins)
RN  - 0 (Scorpion Venoms)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Lethal Dose 50
MH  - Mice
MH  - Proteins/*analysis
MH  - Scorpion Venoms/*chemistry/*toxicity
MH  - Scorpions/*metabolism
EDAT- 2007/05/29 09:00
MHDA- 2007/11/14 09:00
CRDT- 2007/05/29 09:00
PHST- 2007/04/13 00:00 [received]
PHST- 2007/04/13 00:00 [accepted]
PHST- 2007/05/29 09:00 [pubmed]
PHST- 2007/11/14 09:00 [medline]
PHST- 2007/05/29 09:00 [entrez]
AID - S0041-0101(07)00151-1 [pii]
AID - 10.1016/j.toxicon.2007.04.010 [doi]
PST - ppublish
SO  - Toxicon. 2007 Sep 1;50(3):394-9. doi: 10.1016/j.toxicon.2007.04.010. Epub 2007 
      Apr 27.