PMID- 17537512
OWN - NLM
STAT- MEDLINE
DCOM- 20080306
LR  - 20171116
IS  - 0147-6513 (Print)
IS  - 0147-6513 (Linking)
VI  - 69
IP  - 2
DP  - 2008 Feb
TI  - Effects of tebufenozide on some aspects of lake trout (Salvelinus namaycush) 
      immune response.
PG  - 173-9
AB  - Tebufenozide is a nonsteroid ecdysone agonist that causes premature and 
      incomplete molting in Lepidoptera and is used on crops and in forest spray 
      programs. Lake trout (Salvelinus namaycush) were exposed to one pulse of 0.25 ppm 
      tebufenozide every 3 days (12 pulses in total). Cell ratios and respiratory burst 
      responses of circulating white blood cells (WBCs) as well as head-kidney (HK) 
      WBCs were investigated by using cell observation, Nitro-Blue Tetrazolium tests, 
      and flow cytometry. Endpoints studied suggest a difference in sensitivity between 
      HK and circulating blood cells to tebufenozide and show a stimulation of fish 
      cell function and changes in percentages of cell types. Responses are not 
      associated with a strong stress response as highlighted by the absence of effect 
      on cortisol and blood protein levels. These results and tebufenozide persistence 
      in water warrant further studies on pesticide impact on fish immunity when used 
      on crops or in forest spray programs near lakes and streams.
FAU - Hamoutene, D
AU  - Hamoutene D
AD  - Science Branch, Department of Fisheries and Oceans-NWAFC, PO Box 5667, St John's, 
      NL, Canada A1C 5X1. Hamoutened@dfo-mpo.gc.ca
FAU - Payne, J F
AU  - Payne JF
FAU - Volkoff, H
AU  - Volkoff H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070529
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Fish Proteins)
RN  - 0 (Hydrazines)
RN  - 0 (Insecticides)
RN  - 0 (Water Pollutants, Chemical)
RN  - TNN5MI5EKF (tebufenozide)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Animals
MH  - Fish Proteins/blood
MH  - Hydrazines/*toxicity
MH  - Hydrocortisone/blood
MH  - Insecticides/*toxicity
MH  - Leukocyte Count
MH  - Leukocytes/cytology/*drug effects/metabolism
MH  - Respiratory Burst/drug effects
MH  - Salmonidae/blood/*physiology
MH  - Water Pollutants, Chemical/*toxicity
EDAT- 2007/06/01 09:00
MHDA- 2008/03/07 09:00
CRDT- 2007/06/01 09:00
PHST- 2006/10/24 00:00 [received]
PHST- 2007/04/02 00:00 [revised]
PHST- 2007/04/09 00:00 [accepted]
PHST- 2007/06/01 09:00 [pubmed]
PHST- 2008/03/07 09:00 [medline]
PHST- 2007/06/01 09:00 [entrez]
AID - S0147-6513(07)00078-4 [pii]
AID - 10.1016/j.ecoenv.2007.04.012 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2008 Feb;69(2):173-9. doi: 10.1016/j.ecoenv.2007.04.012. 
      Epub 2007 May 29.