PMID- 17538194
OWN - NLM
STAT- MEDLINE
DCOM- 20070911
LR  - 20191110
IS  - 0953-4180 (Print)
IS  - 1875-8584 (Electronic)
IS  - 0953-4180 (Linking)
VI  - 18
IP  - 2
DP  - 2007
TI  - Perceived behavioral changes in early multiple sclerosis.
PG  - 81-90
AB  - Acquired behavioral changes have essentially been described in advanced multiple 
      sclerosis (MS). The present study was designed to determine whether behavioral 
      modifications specifically related to the MS pathological process could be 
      identified in the initial phase of the disease, as compared to control patients 
      with chronic, relapsing and progressive inflammatory disorders not involving the 
      central nervous system (CNS). Eighty-eight early MS patients (Expanded Disability 
      Status Scale score <or= 2.5) and 48 controls were tested. Perceived changes by 
      informants in behavioral control, goal-directed behavior, decision making, 
      emotional expression, insight and interpersonal relationships were assessed using 
      the Iowa Scale of Personality Change (ISPC). Executive behavioral disturbances 
      were screened using the Dysexecutive Questionnaire (DEX). The mean change between 
      the premorbid and postmorbid ISPC ratings was similar in the MS [12.2 (SD 15.6)] 
      and in the control [11.5 (SD 15.1)] group. The perceived behavioral changes 
      (PBCs) most frequently reported in both groups were lack of stamina, 
      lability/moodiness, anxiety, vulnerability to stress and irritability. 
      Pathological scores in the DEX were also similar in both groups. Correlations 
      between PBCs and DEX scores were different in MS and control groups. MS patients 
      with cognitive impairment had a marginally higher number of PBCs than control 
      patients (p=0.056) and a significantly higher DEXp score (p=0.04). These results 
      suggest that (1) PBCs occurring in early MS patients were not different from 
      those induced by comparable chronic non-CNS disorders, (2) qualitative 
      differences in the relationship between behavioral symptoms and 
      executive-behavioral changes may exist between MS and control groups, and (3) 
      behavioral symptoms seem associated with cognitive deficits in MS. We further 
      plan to assess these observations longitudinally.
FAU - Lima, Fabiana Souza
AU  - Lima FS
AD  - Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne, 
      Switzerland.
FAU - Simioni, Samanta
AU  - Simioni S
FAU - Bruggimann, Laure
AU  - Bruggimann L
FAU - Ruffieux, Christiane
AU  - Ruffieux C
FAU - Dudler, Jean
AU  - Dudler J
FAU - Felley, Christian
AU  - Felley C
FAU - Michetti, Pierre
AU  - Michetti P
FAU - Annoni, Jean-Marie
AU  - Annoni JM
FAU - Schluep, Myriam
AU  - Schluep M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Behav Neurol
JT  - Behavioural neurology
JID - 8914585
SB  - IM
MH  - Adult
MH  - Affective Symptoms/complications/physiopathology/*psychology
MH  - Anxiety/complications/*psychology
MH  - Case-Control Studies
MH  - Chronic Disease/psychology
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/complications/physiopathology/*psychology
MH  - Personality Assessment
MH  - Physical Endurance
MH  - Psychiatric Status Rating Scales
MH  - *Self-Assessment
MH  - Severity of Illness Index
MH  - Sex Factors
PMC - PMC5469952
EDAT- 2007/06/01 09:00
MHDA- 2007/09/12 09:00
PMCR- 2007/05/30
CRDT- 2007/06/01 09:00
PHST- 2007/06/01 09:00 [pubmed]
PHST- 2007/09/12 09:00 [medline]
PHST- 2007/06/01 09:00 [entrez]
PHST- 2007/05/30 00:00 [pmc-release]
AID - 10.1155/2007/674075 [doi]
PST - ppublish
SO  - Behav Neurol. 2007;18(2):81-90. doi: 10.1155/2007/674075.