PMID- 17538639
OWN - NLM
STAT- MEDLINE
DCOM- 20070828
LR  - 20131121
IS  - 0955-9930 (Print)
IS  - 0955-9930 (Linking)
VI  - 19
IP  - 4
DP  - 2007 Jul-Aug
TI  - Transdermal testosterone gel increases serum testosterone levels in hypogonadal 
      men in Taiwan with improvements in sexual function.
PG  - 411-7
AB  - A randomized, double-blind, placebo-controlled trial was conducted to (1) 
      evaluate efficacy and safety of transdermal testosterone gel (AndroGel) for 
      hypogonadal men in Taiwan, and (2) observe improvements in sexual function 
      through international index of erectile function (IIEF) scores. Eligible 
      hypogonadal men were randomized to receive 50 mg/day transdermal testosterone gel 
      (TTG) or placebo for 3 months. Primary end point was change from baseline in 
      total testosterone (TT) and free testosterone (FT). Secondary end points were 
      change from baseline in serum hormone levels (such as dihydrotestosterone (DHT), 
      estradiol (E2), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and 
      sex-hormone-binding globulin (SHBG)) and changes in IIEF scores. Safety 
      evaluations included adverse events (AEs) and skin irritation assessment. 
      Compared with baseline, the TTG group (n=20) had statistically significant 
      increases in mean TT levels at month 1 (P=0.024) and month 2 (P=0.025), but no 
      significant changes at month 3. TT levels in the placebo group (n=18) showed no 
      statistically significant change at any visit. Changes in FT levels paralleled 
      changes in TT levels in both groups. TTG group IIEF scores were significantly 
      increased at month 3 (P=0.01), compared with a decline in placebo scores. No 
      drug-related AEs occurred in the TTG group; the placebo group had 2 AEs (mild 
      skin rash). In conclusion, TTG effectively restores serum TT and FT levels to a 
      normal physiological range for hypogonadal men in Taiwan and improves sexual 
      function.
FAU - Chiang, H S
AU  - Chiang HS
AD  - Division of Urology, Department of Surgery, Shin Kong WHS Memorial Hospital, 
      Taipei, Taiwan, ROC.
FAU - Hwang, T I S
AU  - Hwang TI
FAU - Hsui, Y S
AU  - Hsui YS
FAU - Lin, Y C
AU  - Lin YC
FAU - Chen, H E
AU  - Chen HE
FAU - Chen, G C
AU  - Chen GC
FAU - Liao, C H
AU  - Liao CH
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20070531
PL  - England
TA  - Int J Impot Res
JT  - International journal of impotence research
JID - 9007383
RN  - 0 (Gonadal Steroid Hormones)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Administration, Cutaneous
MH  - Adult
MH  - Aged
MH  - Double-Blind Method
MH  - Erectile Dysfunction/drug therapy/etiology
MH  - Gonadal Steroid Hormones/blood
MH  - Humans
MH  - Hypogonadism/*blood/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Penile Erection/physiology/psychology
MH  - Pilot Projects
MH  - Prospective Studies
MH  - Sexuality/*drug effects
MH  - Taiwan
MH  - Testosterone/*administration & dosage/blood/*therapeutic use
EDAT- 2007/06/01 09:00
MHDA- 2007/08/29 09:00
CRDT- 2007/06/01 09:00
PHST- 2007/06/01 09:00 [pubmed]
PHST- 2007/08/29 09:00 [medline]
PHST- 2007/06/01 09:00 [entrez]
AID - 3901562 [pii]
AID - 10.1038/sj.ijir.3901562 [doi]
PST - ppublish
SO  - Int J Impot Res. 2007 Jul-Aug;19(4):411-7. doi: 10.1038/sj.ijir.3901562. Epub 
      2007 May 31.