PMID- 17538883
OWN - NLM
STAT- MEDLINE
DCOM- 20070730
LR  - 20160129
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 196
IP  - 1
DP  - 2007 Jul 1
TI  - Evolution of HIV-1 in an HLA-B*57-positive patient during virologic escape.
PG  - 50-5
AB  - Elite suppressors maintain normal CD4(+) T cell counts and viral loads of <50 
      copies of human immunodeficiency virus type 1 (HIV-1) RNA per milliliter of 
      plasma without antiviral therapy. We report here a case of virologic escape in a 
      human leukocyte antigen (HLA)-B*57-positive patient shortly after seroconversion. 
      This escape was associated with the development of mutations in 2 
      HLA-B*57-restricted CD8(+) T cell Gag epitopes, reversion of the drug-resistance 
      mutation M184V, and reversion of a novel polymorphism in Vpu. The present study 
      suggests that control of viral replication in elite suppressors may be due to 
      HIV-1-specific CD8(+) T cells and, in some cases, mutations that have subtle 
      effects on viral fitness.
FAU - Bailey, Justin R
AU  - Bailey JR
AD  - Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, 
      USA.
FAU - Zhang, Haili
AU  - Zhang H
FAU - Wegweiser, Barbara W
AU  - Wegweiser BW
FAU - Yang, Hung-Chih
AU  - Yang HC
FAU - Herrera, Laura
AU  - Herrera L
FAU - Ahonkhai, Aima
AU  - Ahonkhai A
FAU - Williams, Thomas M
AU  - Williams TM
FAU - Siliciano, Robert F
AU  - Siliciano RF
FAU - Blankson, Joel N
AU  - Blankson JN
LA  - eng
SI  - GENBANK/EF125548
SI  - GENBANK/EF125549
SI  - GENBANK/EF125550
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SI  - GENBANK/EF125658
SI  - GENBANK/EF125659
GR  - K08 AI51191-04/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20070517
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Epitopes, T-Lymphocyte)
RN  - 0 (Gene Products, gag)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B57 antigen)
RN  - 0 (Human Immunodeficiency Virus Proteins)
RN  - 0 (RNA, Viral)
RN  - 0 (Viral Regulatory and Accessory Proteins)
RN  - 0 (vpu protein, Human immunodeficiency virus 1)
SB  - IM
MH  - Adult
MH  - Amino Acid Substitution/genetics
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - DNA Mutational Analysis
MH  - Drug Resistance, Viral/genetics
MH  - Epitopes, T-Lymphocyte/genetics
MH  - *Evolution, Molecular
MH  - Gene Products, gag/genetics
MH  - Genome, Viral/*genetics
MH  - HIV Infections/genetics/*immunology/*virology
MH  - HIV-1/*genetics/isolation & purification
MH  - HLA-B Antigens/*genetics
MH  - Human Immunodeficiency Virus Proteins
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - Mutation, Missense
MH  - RNA, Viral/*genetics
MH  - Viral Regulatory and Accessory Proteins/genetics
EDAT- 2007/06/01 09:00
MHDA- 2007/07/31 09:00
CRDT- 2007/06/01 09:00
PHST- 2006/12/13 00:00 [received]
PHST- 2007/02/01 00:00 [accepted]
PHST- 2007/06/01 09:00 [pubmed]
PHST- 2007/07/31 09:00 [medline]
PHST- 2007/06/01 09:00 [entrez]
AID - JID37997 [pii]
AID - 10.1086/518515 [doi]
PST - ppublish
SO  - J Infect Dis. 2007 Jul 1;196(1):50-5. doi: 10.1086/518515. Epub 2007 May 17.