PMID- 17539508
OWN - NLM
STAT- MEDLINE
DCOM- 20070629
LR  - 20190715
IS  - 0013-936X (Print)
IS  - 0013-936X (Linking)
VI  - 41
IP  - 9
DP  - 2007 May 1
TI  - Lipid reserve dynamics and magnification of persistent organic pollutants in 
      spawning sockeye salmon (Oncorhynchus nerka) from the Fraser River, British 
      Columbia.
PG  - 3083-9
AB  - Pacific sockeye salmon (Oncorhynchus nerka) can travel several hundred kilometers 
      to reach native spawning grounds and fulfill semelparous reproduction. The 
      dramatic changes in lipid reserves during upstream migration can greatly affect 
      internal toxicokinetics of persistent organic pollutants (POPs) such as PCBs, 
      PCDDs, and PCDFs. We measured lipid content changes and contaminant 
      concentrations in tissues (liver, muscle, roe/gonads) and biomarker responses 
      (ethoxyresorufin O-deethylase or EROD activity and CYP1A levels) in two Pacific 
      sockeye salmon stocks sampled at several locations along their spawning migration 
      in the Fraser River, British Columbia. Muscle lipid contents declined 
      significantly with increasing upstream migration distance and corresponded to 
      elevated lipid normalized concentrations of PCBs and PCDD/Fs in spawning sockeye. 
      Post-migration magnification factors (MFs) in spawning sockeye ranged between 3 
      and 12 and were comparable to model-predicted MFs. sigmaPCBs(150-500 ng x g(-1) 
      lipid), sigmaPCDD/Fs (1-1000 pg x g(-1) lipid) and 2,3,7,8-TCDD toxic equivalent 
      or TEQ levels (0.1-15 pg x g(-1) lipid) in spawning sockeye were relatively low 
      and did not affect hepatic EROD activity/CYP1A induction. Despite a 3-fold 
      magnification, TEQ levels in eggs of spawning Fraser River sockeye did not exceed 
      0.3 pg x g(-1) wet wt, a threshold level associated with 30% egg mortality in 
      salmonids. PCBs in Fraser River sockeye are comparable to previous levels in 
      Pacific sockeye. In contrast to Pacific sockeye from more remote coastal 
      locations, PCDDs and PCDFs in Fraser River sockeye were generally minor 
      components (<25%) of TEQ levels, compared to dioxin like PCB contributions 
      (>75%). The data suggest that (i) the Fraser River is not a major contamination 
      source of PCBs or PCDD/Fs and (ii) marine contaminant distribution, food-chain 
      dynamics, and ocean-migration pathway are likely important factors controlling 
      levels and patterns of POPs in returning Pacific sockeye. We estimate an annual 
      chemical flux entering the Fraser River of up to 150 g for sigmaPCBs and 40 mg 
      for sigmaPCDD/ Fs via returning sockeye. The results indicate that historical 
      concentrations of PCBs and PCDD/Fs remain a potential threat to organism and 
      ecosystem health on the west coast of Canada.
FAU - Kelly, Barry C
AU  - Kelly BC
AD  - Contaminant Sciences, Institute of Ocean Sciences, Fisheries and Oceans Canada 
      (DFO), 9860 West Saanich Road, Sidney, British Columbia, Canada.
FAU - Gray, Samantha L
AU  - Gray SL
FAU - Ikonomou, Michael G
AU  - Ikonomou MG
FAU - Macdonald, J Steve
AU  - Macdonald JS
FAU - Bandiera, Stelvio M
AU  - Bandiera SM
FAU - Hrycay, Eugene G
AU  - Hrycay EG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Benzofurans)
RN  - 0 (Dibenzofurans, Polychlorinated)
RN  - 0 (Lipids)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Water Pollutants, Chemical)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
MH  - Animals
MH  - Benzofurans/*metabolism
MH  - British Columbia
MH  - Cytochrome P-450 CYP1A1/metabolism
MH  - Dibenzofurans, Polychlorinated
MH  - Environmental Monitoring
MH  - Female
MH  - Gonads/metabolism
MH  - Lipids/chemistry
MH  - Liver/metabolism
MH  - Male
MH  - Microsomes, Liver/enzymology
MH  - Muscles/metabolism
MH  - Ovum/metabolism
MH  - Polychlorinated Biphenyls/*metabolism
MH  - Polychlorinated Dibenzodioxins/*analogs & derivatives/metabolism
MH  - Rivers
MH  - Salmon/*metabolism
MH  - Water Pollutants, Chemical/*metabolism
EDAT- 2007/06/02 09:00
MHDA- 2007/06/30 09:00
CRDT- 2007/06/02 09:00
PHST- 2007/06/02 09:00 [pubmed]
PHST- 2007/06/30 09:00 [medline]
PHST- 2007/06/02 09:00 [entrez]
AID - 10.1021/es061559n [doi]
PST - ppublish
SO  - Environ Sci Technol. 2007 May 1;41(9):3083-9. doi: 10.1021/es061559n.