PMID- 17539941
OWN - NLM
STAT- MEDLINE
DCOM- 20070710
LR  - 20151113
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 14
IP  - 6
DP  - 2007 Jun
TI  - A comparative study of chronic inflammatory demyelinating polyradiculoneuropathy 
      with and without diabetes mellitus.
PG  - 638-43
AB  - Diabetes mellitus (DM) is occasionally associated with chronic inflammatory 
      demyelinating polyradiculoneuropathy (CIDP) raising the question of coexistence 
      or etiological link. The study compares, neurophysiological and outcome of CIDP 
      patients with and without DM. Consecutive CIDP patients were subjected to 
      detailed clinical evaluation, haematology, serum chemistry, vasculitis profile, 
      paraproteins, myeloma screening and cerebrospinal fluid (CSF) examination. 
      Electrodiagnostic (EDx) tests included motor and sensory conduction and F-wave 
      studies. The patients were treated with oral prednisolone 1 mg/kg/day with or 
      without azathioprine 1-2 mg/kg and followed up for 6 months. The clinical and EDx 
      finding in CIDP with and without DM were compared. Thirty-five CIDP patients were 
      included and nine had DM. CIDP with diabetes (CIDP-D) had higher frequency of 
      autonomic dysfunction. In CIDP-D, motor (38.9% vs. 16.7%) and sensory (40.7% vs. 
      14.1%) nerve conductions were more frequently unrecordable or had reduced 
      compound muscle action potential (CMAP) amplitude. F-waves were also more 
      frequently unrecordable in CIDP-D (28.8% vs. 12.8%) compared with idiopathic CIDP 
      (I-CIDP). The degree of conduction block was more in I-CIDP. At 6-month follow 
      up, I-CIDP patients improved better than CIDP-D. CIDP-D patients present with 
      higher frequency of autonomic dysfunction, electrophysiological evidences of 
      associated axonal loss and had a poorer outcome at 6 months compared with I-CIDP.
FAU - Kalita, J
AU  - Kalita J
AD  - Department of Neurology, Sanjay Gandhi PGIMS, Lucknow, India.
FAU - Misra, U K
AU  - Misra UK
FAU - Yadav, R K
AU  - Yadav RK
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
RN  - 0 (Anti-Inflammatory Agents)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Anti-Inflammatory Agents/therapeutic use
MH  - Chi-Square Distribution
MH  - Diabetes Mellitus/drug therapy/*physiopathology
MH  - Disability Evaluation
MH  - Electrodiagnosis/methods
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neural Conduction/drug effects/physiology
MH  - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/*complications/drug 
      therapy
MH  - Prednisolone/therapeutic use
MH  - Time Factors
EDAT- 2007/06/02 09:00
MHDA- 2007/07/11 09:00
CRDT- 2007/06/02 09:00
PHST- 2007/06/02 09:00 [pubmed]
PHST- 2007/07/11 09:00 [medline]
PHST- 2007/06/02 09:00 [entrez]
AID - ENE1798 [pii]
AID - 10.1111/j.1468-1331.2007.01798.x [doi]
PST - ppublish
SO  - Eur J Neurol. 2007 Jun;14(6):638-43. doi: 10.1111/j.1468-1331.2007.01798.x.