PMID- 17539941 OWN - NLM STAT- MEDLINE DCOM- 20070710 LR - 20151113 IS - 1468-1331 (Electronic) IS - 1351-5101 (Linking) VI - 14 IP - 6 DP - 2007 Jun TI - A comparative study of chronic inflammatory demyelinating polyradiculoneuropathy with and without diabetes mellitus. PG - 638-43 AB - Diabetes mellitus (DM) is occasionally associated with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) raising the question of coexistence or etiological link. The study compares, neurophysiological and outcome of CIDP patients with and without DM. Consecutive CIDP patients were subjected to detailed clinical evaluation, haematology, serum chemistry, vasculitis profile, paraproteins, myeloma screening and cerebrospinal fluid (CSF) examination. Electrodiagnostic (EDx) tests included motor and sensory conduction and F-wave studies. The patients were treated with oral prednisolone 1 mg/kg/day with or without azathioprine 1-2 mg/kg and followed up for 6 months. The clinical and EDx finding in CIDP with and without DM were compared. Thirty-five CIDP patients were included and nine had DM. CIDP with diabetes (CIDP-D) had higher frequency of autonomic dysfunction. In CIDP-D, motor (38.9% vs. 16.7%) and sensory (40.7% vs. 14.1%) nerve conductions were more frequently unrecordable or had reduced compound muscle action potential (CMAP) amplitude. F-waves were also more frequently unrecordable in CIDP-D (28.8% vs. 12.8%) compared with idiopathic CIDP (I-CIDP). The degree of conduction block was more in I-CIDP. At 6-month follow up, I-CIDP patients improved better than CIDP-D. CIDP-D patients present with higher frequency of autonomic dysfunction, electrophysiological evidences of associated axonal loss and had a poorer outcome at 6 months compared with I-CIDP. FAU - Kalita, J AU - Kalita J AD - Department of Neurology, Sanjay Gandhi PGIMS, Lucknow, India. FAU - Misra, U K AU - Misra UK FAU - Yadav, R K AU - Yadav RK LA - eng PT - Clinical Trial PT - Comparative Study PT - Journal Article PL - England TA - Eur J Neurol JT - European journal of neurology JID - 9506311 RN - 0 (Anti-Inflammatory Agents) RN - 9PHQ9Y1OLM (Prednisolone) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Anti-Inflammatory Agents/therapeutic use MH - Chi-Square Distribution MH - Diabetes Mellitus/drug therapy/*physiopathology MH - Disability Evaluation MH - Electrodiagnosis/methods MH - Female MH - Follow-Up Studies MH - Humans MH - Male MH - Middle Aged MH - Neural Conduction/drug effects/physiology MH - Polyradiculoneuropathy, Chronic Inflammatory Demyelinating/*complications/drug therapy MH - Prednisolone/therapeutic use MH - Time Factors EDAT- 2007/06/02 09:00 MHDA- 2007/07/11 09:00 CRDT- 2007/06/02 09:00 PHST- 2007/06/02 09:00 [pubmed] PHST- 2007/07/11 09:00 [medline] PHST- 2007/06/02 09:00 [entrez] AID - ENE1798 [pii] AID - 10.1111/j.1468-1331.2007.01798.x [doi] PST - ppublish SO - Eur J Neurol. 2007 Jun;14(6):638-43. doi: 10.1111/j.1468-1331.2007.01798.x.