PMID- 17540368
OWN - NLM
STAT- MEDLINE
DCOM- 20071024
LR  - 20231105
IS  - 0014-4800 (Print)
IS  - 0014-4800 (Linking)
VI  - 83
IP  - 2
DP  - 2007 Oct
TI  - Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injury.
PG  - 169-76
AB  - Mice lacking matrix metalloproteinase-3 (MMP-3; stromelysin-1) demonstrated 
      significantly less injury than their normal counterparts following the formation 
      of IgG-containing immune complexes in the alveolar wall or in the wall of the 
      peritoneum. Likewise, mice lacking MMP-3 demonstrated less lung injury following 
      intra-tracheal instillation of the chemotactic cytokine macrophage inhibitory 
      protein-2 (MIP-2) than did mice with MMP-3. There was a relationship between 
      tissue injury (evidenced histologically) and accumulation of anti-laminin 111 
      immunoreactive material in the bronchoalveolar lavage (BAL) or peritoneal lavage 
      (PL) fluid. There was also a relationship between tissue injury and influx of 
      neutrophils into the BAL or PL fluid. Taken together, these data demonstrate an 
      important role for MMP-3 in acute inflammatory tissue injury.
FAU - Nerusu, Kamalakar C
AU  - Nerusu KC
AD  - Department of Pathology, The University of Michigan Medical School, 1301 
      Catherine Road/Box 0602, Ann Arbor, MI 48109, USA.
FAU - Warner, Roscoe L
AU  - Warner RL
FAU - Bhagavathula, Narasimharao
AU  - Bhagavathula N
FAU - McClintock, Shannon D
AU  - McClintock SD
FAU - Johnson, Kent J
AU  - Johnson KJ
FAU - Varani, James
AU  - Varani J
LA  - eng
GR  - R01 HL070979/HL/NHLBI NIH HHS/United States
GR  - R01 HL070979-03/HL/NHLBI NIH HHS/United States
GR  - HL70979/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20070504
PL  - Netherlands
TA  - Exp Mol Pathol
JT  - Experimental and molecular pathology
JID - 0370711
RN  - 0 (Chemokine CXCL2)
RN  - 0 (Chemokines)
RN  - 0 (Cxcl2 protein, mouse)
RN  - 0 (Immunoglobulin G)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Bronchoalveolar Lavage Fluid/cytology/immunology
MH  - Chemokine CXCL2
MH  - Chemokines/physiology
MH  - Immunoglobulin G/*analysis
MH  - Inflammation/enzymology/immunology/*pathology/prevention & control
MH  - Matrix Metalloproteinase 3/deficiency/genetics/*metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Neutrophils/pathology/physiology
PMC - PMC2062514
MID - NIHMS30769
EDAT- 2007/06/02 09:00
MHDA- 2007/10/25 09:00
PMCR- 2008/10/01
CRDT- 2007/06/02 09:00
PHST- 2006/11/21 00:00 [received]
PHST- 2007/04/02 00:00 [revised]
PHST- 2007/04/04 00:00 [accepted]
PHST- 2007/06/02 09:00 [pubmed]
PHST- 2007/10/25 09:00 [medline]
PHST- 2007/06/02 09:00 [entrez]
PHST- 2008/10/01 00:00 [pmc-release]
AID - S0014-4800(07)00048-2 [pii]
AID - 10.1016/j.yexmp.2007.04.003 [doi]
PST - ppublish
SO  - Exp Mol Pathol. 2007 Oct;83(2):169-76. doi: 10.1016/j.yexmp.2007.04.003. Epub 
      2007 May 4.