PMID- 17540666
OWN - NLM
STAT- MEDLINE
DCOM- 20071113
LR  - 20220310
IS  - 1360-9947 (Print)
IS  - 1360-9947 (Linking)
VI  - 13
IP  - 8
DP  - 2007 Aug
TI  - Allelic estrogen receptor 1 (ESR1) gene variants predict the outcome of ovarian 
      stimulation in in vitro fertilization.
PG  - 521-6
AB  - The outcome of in vitro fertilization (IVF) depends substantially on the 
      effectiveness of controlled ovarian hyperstimulation (COH) induced by 
      administration of follicle-stimulating hormone (FSH). In COH, endogenously 
      produced estrogens extend the action of FSH in stimulating folliculogenesis. We 
      determined the associations between genetic variations in estrogen receptor ESR1 
      and ESR2 genes and etiology of female infertility, and analysed the influence of 
      these variations on COH outcome-the quantity and quality of oocytes retrieved. 
      ESR1 PvuII T/C (rs2234693) and XbaI A/G (rs9340799) single-nucleotide 
      polymorphisms (SNPs) and (TA)n microsatellite polymorphism, as well as ESR2 RsaI 
      G/A (rs1256049) SNP and (CA)n microsatellite polymorphism were genotyped in 159 
      IVF patients. The ovarian response to FSH was diminished in patients with 
      endometriosis when compared to tubal factor infertility. ESR1 PvuII and XbaI as 
      well as ESR2 RsaI SNPs were associated with the microsatellite length of the 
      respective genes. Shorter ESR1 (TA)n was linked with a higher risk for 
      unexplained infertility, whereas longer ESR1 (TA)n associated with PvuII*C allele 
      were predictive of a better COH, but not clinical pregnancy outcome in an 
      age-independent manner. These data suggest the variations in ESR1 gene, in 
      addition to the age of a woman, may predict the COH outcome in IVF.
FAU - Altmae, Signe
AU  - Altmae S
AD  - Department of Biotechnology, Institute of Molecular and Cell Biology, Estonian 
      Genome Project, University of Tartu, Estonia, and Department of Clinical Science, 
      Intervention and Technology, Karolinska University Hospital Huddinge, Stockholm, 
      Sweden.
FAU - Haller, Kadri
AU  - Haller K
FAU - Peters, Maire
AU  - Peters M
FAU - Hovatta, Outi
AU  - Hovatta O
FAU - Stavreus-Evers, Anneli
AU  - Stavreus-Evers A
FAU - Karro, Helle
AU  - Karro H
FAU - Metspalu, Andres
AU  - Metspalu A
FAU - Salumets, Andres
AU  - Salumets A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070530
PL  - England
TA  - Mol Hum Reprod
JT  - Molecular human reproduction
JID - 9513710
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Estrogen Receptor alpha/*genetics
MH  - Estrogen Receptor beta/genetics
MH  - Female
MH  - *Fertilization in Vitro
MH  - Follicle Stimulating Hormone/*therapeutic use
MH  - Humans
MH  - Infertility, Female/genetics/*therapy
MH  - Microsatellite Repeats/genetics
MH  - *Ovulation Induction
MH  - Polymorphism, Single Nucleotide
MH  - Pregnancy
MH  - Pregnancy Outcome/*genetics
MH  - Prognosis
EDAT- 2007/06/02 09:00
MHDA- 2007/11/14 09:00
CRDT- 2007/06/02 09:00
PHST- 2007/06/02 09:00 [pubmed]
PHST- 2007/11/14 09:00 [medline]
PHST- 2007/06/02 09:00 [entrez]
AID - gam035 [pii]
AID - 10.1093/molehr/gam035 [doi]
PST - ppublish
SO  - Mol Hum Reprod. 2007 Aug;13(8):521-6. doi: 10.1093/molehr/gam035. Epub 2007 May 
      30.