PMID- 17541394
OWN - NLM
STAT- MEDLINE
DCOM- 20070925
LR  - 20211203
IS  - 0887-6924 (Print)
IS  - 0887-6924 (Linking)
VI  - 21
IP  - 8
DP  - 2007 Aug
TI  - Transplantation of mesenchymal stem cells to enhance engraftment of hematopoietic 
      stem cells.
PG  - 1733-8
AB  - Seven patients underwent treatment with mesenchymal stem cells (MSCs), together 
      with allogeneic hematopoietic stem cell transplantation (HSCT). MSCs were given 
      to three patients for graft failure and four patients were included in a pilot 
      study. HSCT donors were three human leukocyte antigen (HLA)-identical siblings, 
      three unrelated donors and one cord blood unit. The conditioning was 
      myeloablative in four patients and reduced in three patients. MSC donors were 
      HLA-identical siblings in three cases and haploidentical in four cases. 
      Neutrophil counts >0.5 x 10(9)/l was reached at a median of 12 (range 10-28) 
      days. Platelet counts >30 x 10(9)/l was achieved at a median of 12 (8-36) days. 
      Acute graft-versus-host disease (GVHD) grade 0-I was seen in five patients. Two 
      patients developed grade II, which in one patient evolved into chronic GVHD. One 
      severe combined immunodeficiency (SCID) patient died of aspergillosis, the others 
      are alive and well. One patient, diagnosed with aplastic anemia had graft failure 
      after her first transplantation and severe Henoch-Schonlein Purpura (HSP). After 
      retransplantation of MSCs and HSCs, she recovered from both the HSP and aplasia. 
      Thus, co-transplantation of MSC resulted in fast engraftment of absolute 
      neutrophil count (ANC) and platelets and 100% donor chimerism, even in three 
      patients regrafted for graft failure/rejection.
FAU - Le Blanc, K
AU  - Le Blanc K
AD  - Hematology Center, Karolinska Institutet, Karolinska University Hospital 
      Huddinge, Stockholm, Sweden. katarina.leblanc@ki.se
FAU - Samuelsson, H
AU  - Samuelsson H
FAU - Gustafsson, B
AU  - Gustafsson B
FAU - Remberger, M
AU  - Remberger M
FAU - Sundberg, B
AU  - Sundberg B
FAU - Arvidson, J
AU  - Arvidson J
FAU - Ljungman, P
AU  - Ljungman P
FAU - Lonnies, H
AU  - Lonnies H
FAU - Nava, S
AU  - Nava S
FAU - Ringden, O
AU  - Ringden O
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070531
PL  - England
TA  - Leukemia
JT  - Leukemia
JID - 8704895
SB  - IM
MH  - Adult
MH  - Anemia, Aplastic/*therapy
MH  - Cell Proliferation
MH  - Child
MH  - Child, Preschool
MH  - Disease-Free Survival
MH  - Female
MH  - *Graft Survival
MH  - Graft vs Host Disease/prevention & control
MH  - Hematologic Neoplasms/*therapy
MH  - Hematopoietic Stem Cell Transplantation
MH  - Hematopoietic Stem Cells/*cytology
MH  - Histocompatibility Testing
MH  - Humans
MH  - IgA Vasculitis/*therapy
MH  - Infant
MH  - Male
MH  - *Mesenchymal Stem Cell Transplantation
MH  - Pilot Projects
MH  - Siblings
MH  - Transplantation Chimera
MH  - Transplantation Conditioning
MH  - Transplantation, Homologous
EDAT- 2007/06/02 09:00
MHDA- 2007/09/26 09:00
CRDT- 2007/06/02 09:00
PHST- 2007/06/02 09:00 [pubmed]
PHST- 2007/09/26 09:00 [medline]
PHST- 2007/06/02 09:00 [entrez]
AID - 2404777 [pii]
AID - 10.1038/sj.leu.2404777 [doi]
PST - ppublish
SO  - Leukemia. 2007 Aug;21(8):1733-8. doi: 10.1038/sj.leu.2404777. Epub 2007 May 31.