PMID- 17541441
OWN - NLM
STAT- MEDLINE
DCOM- 20070921
LR  - 20230210
IS  - 0893-3952 (Print)
IS  - 0893-3952 (Linking)
VI  - 20
IP  - 8
DP  - 2007 Aug
TI  - Predominance of the basal type and HER-2/neu type in brain metastasis from breast 
      cancer.
PG  - 864-70
AB  - Although breast cancer is the second most common cause of central nervous system 
      (CNS) metastases with a notable increase of incidence, only few studies on 
      brain-metastasizing breast cancer are available. In this immunohistochemical and 
      fluorescence in situ hybridization (FISH) study, metastases to the CNS (n=85) and 
      primary breast cancers, with known involvement of the CNS (n=44) including paired 
      primary and metastasized tumours (n=23), were investigated retrospectively for 
      the expression of oestrogen- (ER) and progesterone- (PR) hormone receptors, 
      Her-2/neu, epidermal growth factor receptor (EGFR), Ki-67, and cytokeratins (CKs) 
      5/14. The majority of brain metastases were steroid hormone receptor negative (ER 
      66%, PR 82%) corresponding to the findings in primary tumours with known 
      involvement of the CNS (68% ER-negative, 75% PR-negative). The frequency of 
      HER-2/neu-overexpressing or -amplified cancers was increased in both groups (34 
      and 32%, respectively). EGFR expression was more frequent in metastases (41%) 
      than in primary tumours (16%). The proportions of cases with a basal phenotype 
      were 26 and 30%, respectively. In paired primary tumours and metastases to the 
      CNS, constancy of Her-2/neu status was observed in 87% of cases with only one 
      sample turning Her-2/neu-negative and two samples acquiring 
      overexpression/amplification in brain metastases. In contrast, steroid hormone 
      receptors exhibited more frequently a loss of expression (17%) than a gain (9%) 
      with 74% revealing a constant phenotype. We conclude that brain-metastasizing 
      breast cancer belongs predominantly to the basal type or Her-2/neu type. Primary 
      and metastatic tumours differ from each other only in a minority of cases, 
      leading rather to a loss of steroid hormone receptors and to a gain of EGFR and 
      Her-2/neu.
FAU - Gaedcke, Jochen
AU  - Gaedcke J
AD  - Institute of Pathology, Medizinische Hochschule Hannover, Hannover, Germany.
FAU - Traub, Frank
AU  - Traub F
FAU - Milde, Simone
AU  - Milde S
FAU - Wilkens, Ludwig
AU  - Wilkens L
FAU - Stan, Alexandru
AU  - Stan A
FAU - Ostertag, Helmut
AU  - Ostertag H
FAU - Christgen, Mathias
AU  - Christgen M
FAU - von Wasielewski, Reinhard
AU  - von Wasielewski R
FAU - Kreipe, Hans H
AU  - Kreipe HH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070601
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - 0 (KRT14 protein, human)
RN  - 0 (KRT5 protein, human)
RN  - 0 (Keratin-14)
RN  - 0 (Keratin-5)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (ErbB Receptors)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Brain Neoplasms/*chemistry/genetics/secondary
MH  - Breast Neoplasms/*chemistry/genetics/pathology
MH  - Cell Proliferation
MH  - ErbB Receptors/analysis
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry/methods
MH  - In Situ Hybridization, Fluorescence
MH  - Keratin-14/analysis
MH  - Keratin-5/analysis
MH  - Ki-67 Antigen/analysis
MH  - Neoplasms, Basal Cell/*chemistry/genetics/secondary
MH  - Receptor, ErbB-2/*analysis/genetics
MH  - Receptors, Estrogen/analysis
MH  - Receptors, Progesterone/analysis
MH  - Retrospective Studies
MH  - Tissue Array Analysis
EDAT- 2007/06/02 09:00
MHDA- 2007/09/22 09:00
CRDT- 2007/06/02 09:00
PHST- 2007/06/02 09:00 [pubmed]
PHST- 2007/09/22 09:00 [medline]
PHST- 2007/06/02 09:00 [entrez]
AID - S0893-3952(22)03282-3 [pii]
AID - 10.1038/modpathol.3800830 [doi]
PST - ppublish
SO  - Mod Pathol. 2007 Aug;20(8):864-70. doi: 10.1038/modpathol.3800830. Epub 2007 Jun 
      1.