PMID- 17543031
OWN - NLM
STAT- MEDLINE
DCOM- 20080115
LR  - 20070604
IS  - 1398-5647 (Print)
IS  - 1398-5647 (Linking)
VI  - 9 Suppl 1
DP  - 2007 Jun
TI  - Traumatic life events in bipolar disorder: impact on BDNF levels and 
      psychopathology.
PG  - 128-35
AB  - BACKGROUND: There is evidence that vulnerability to depression and anxiety 
      disorders is markedly increased by traumatic life events. While childhood abuse 
      has been reported to be associated with poorer outcomes in bipolar disorder, 
      little is known about the neurobiological basis underlying this association. The 
      aim of this study was to ascertain whether bipolar patients who were exposed to a 
      traumatic event or events (TE) have lower brain-derived neurotrophic factor 
      (BDNF) levels and more severe psychopathology as indicated by increased 
      comorbidity and other clinical features when compared to those who were not 
      exposed to TE. METHODS: One-hundred and sixty-three consecutively recruited 
      bipolar outpatients were assessed by Structured Clinical Interview for DSM-IV 
      (SCID) and standard protocol in order to evaluation psychopathology and clinical 
      features. The reported TE was assessed using DSM-IV stem criteria for trauma (as 
      defined by A1 and A2 criteria for trauma for post-traumatic stress disorder). 
      Subjects were divided into 2 groups according to presence or absence of lifetime 
      TE. The levels of BDNF, comorbidity and other clinical features were compared 
      between groups. RESULTS: After adjusting for confounders, results indicated that 
      bipolar patients with a history of TE have alcohol abuse/dependence (p < 0.001), 
      anxiety comorbidity, and lower levels of serum BDNF (p < 0.01) compared to those 
      without a history of TE. There was no difference between the 2 groups in age of 
      onset, presence of psychosis, other substance abuse and dependence, rapid cycling 
      or suicide attempts. CONCLUSIONS: Our findings suggest that TE are associated 
      with significantly increased prevalence of alcohol and anxiety comorbidity as 
      well as lower BDNF levels in bipolar patients. It is possible that a decrease in 
      BDNF levels may account for increased comorbidity, but further prospective 
      studies are required to confirm this.
FAU - Kauer-Sant'Anna, Marcia
AU  - Kauer-Sant'Anna M
AD  - Post-Graduate Biochemistry Program, Federal University of Rio Grande do Sul, 
      Porto Alegre, RS, Brazil.
FAU - Tramontina, Juliana
AU  - Tramontina J
FAU - Andreazza, Ana Cristina
AU  - Andreazza AC
FAU - Cereser, Keila
AU  - Cereser K
FAU - da Costa, Sabrina
AU  - da Costa S
FAU - Santin, Aida
AU  - Santin A
FAU - Yatham, Lakshmi N
AU  - Yatham LN
FAU - Kapczinski, Flavio
AU  - Kapczinski F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bipolar Disorder/*complications/epidemiology/etiology/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Diagnostic and Statistical Manual of Mental Disorders
MH  - Female
MH  - Humans
MH  - *Life Change Events
MH  - Male
MH  - Middle Aged
MH  - Psychiatric Status Rating Scales
MH  - *Psychopathology
MH  - Psychotic Disorders/epidemiology/*etiology
MH  - Retrospective Studies
MH  - Stress Disorders, Traumatic/complications
EDAT- 2007/11/22 09:00
MHDA- 2008/01/16 09:00
CRDT- 2007/11/22 09:00
PHST- 2007/11/22 09:00 [pubmed]
PHST- 2008/01/16 09:00 [medline]
PHST- 2007/11/22 09:00 [entrez]
AID - BDI478 [pii]
AID - 10.1111/j.1399-5618.2007.00478.x [doi]
PST - ppublish
SO  - Bipolar Disord. 2007 Jun;9 Suppl 1:128-35. doi: 10.1111/j.1399-5618.2007.00478.x.