PMID- 17543293
OWN - NLM
STAT- MEDLINE
DCOM- 20071012
LR  - 20131121
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1158
DP  - 2007 Jul 16
TI  - Prenatal restraint stress and motherless rearing disrupts expression of 
      plasticity markers and stress-induced corticosterone release in adult female 
      Sprague-Dawley rats.
PG  - 28-38
AB  - This study investigated the effects of prenatal stress and complete maternal 
      deprivation, using the artificial rearing (AR) paradigm, on the expression of 
      neural plasticity markers and hypothalamic-pituitary-adrenal (HPA) axis 
      responsivity to stress. Rats were exposed to stress during gestation (day 10-21) 
      and postnatally were either artificially reared (AR) or mother reared (MR). AR 
      involves complete separation of the pup from both the dam and the litter 
      throughout the pre-weaning period. In adulthood, we measured levels of 
      corticosterone (CORT) in response to restraint stress. Also, we examined the 
      expression of synaptophysin (SYN) and brain-derived neurotrophic factor (BDNF) in 
      the medial prefrontal cortex (MPFC) and the nucleus accumbens (Nacc), areas of 
      the brain that mediate behavioral activation and attention, among other 
      behaviors. Earlier work on the same rats indicated that these behavioral 
      endpoints, such as locomotor activity and sensorimotor gating, are affected by 
      our prenatal and postnatal manipulations. Prenatal stress decreased CORT at 20 
      and 90 min post-stressor in MR, but not in AR, animals. Also, in comparison to MR 
      groups, AR decreased SYN and BDNF expression in the MPFC and Nacc. Additional 
      somatosensory 'licking-like' stroking stimulation partially reversed the effects 
      of AR. Prenatal stress did not have a robust main effect but affected the impact 
      of the postnatal rearing condition on SYN expression and stress-induced CORT. 
      These results suggest that both prenatal and postnatal adversities have an 
      influence on HPA axis responsivity and alter the expression of plasticity related 
      neuronal proteins.
FAU - Burton, Christie L
AU  - Burton CL
AD  - Department of Psychology, University of Toronto at Mississauga, Mississauga, ON, 
      Canada.
FAU - Chatterjee, Diptendu
AU  - Chatterjee D
FAU - Chatterjee-Chakraborty, Munmun
AU  - Chatterjee-Chakraborty M
FAU - Lovic, Vedran
AU  - Lovic V
FAU - Grella, Stephanie L
AU  - Grella SL
FAU - Steiner, Meir
AU  - Steiner M
FAU - Fleming, Alison S
AU  - Fleming AS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070508
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Synaptophysin)
RN  - W980KJ009P (Corticosterone)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal
MH  - Brain/anatomy & histology/growth & development/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corticosterone/*blood
MH  - Female
MH  - Gene Expression Regulation, Developmental/physiology
MH  - Male
MH  - *Maternal Deprivation
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Radioimmunoassay/methods
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Restraint, Physical/methods
MH  - Stress, Psychological/*physiopathology
MH  - Synaptophysin/*metabolism
EDAT- 2007/06/05 09:00
MHDA- 2007/10/13 09:00
CRDT- 2007/06/05 09:00
PHST- 2007/03/28 00:00 [received]
PHST- 2007/04/30 00:00 [revised]
PHST- 2007/05/01 00:00 [accepted]
PHST- 2007/06/05 09:00 [pubmed]
PHST- 2007/10/13 09:00 [medline]
PHST- 2007/06/05 09:00 [entrez]
AID - S0006-8993(07)01062-1 [pii]
AID - 10.1016/j.brainres.2007.05.003 [doi]
PST - ppublish
SO  - Brain Res. 2007 Jul 16;1158:28-38. doi: 10.1016/j.brainres.2007.05.003. Epub 2007 
      May 8.