PMID- 17543994
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20091119
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 260
IP  - 1-2
DP  - 2007 Sep 15
TI  - Cytogenetic aberrations in neuropathy associated with IgM monoclonal gammopathy.
PG  - 124-31
AB  - The occurrence and nature of cytogenetic aberrations in polyneuropathy associated 
      with IgM monoclonal gammopathy was determined. Therefore, interphase fluorescence 
      in situ hybridization (FISH) was applied in 22 patients with polyneuropathy 
      associated with IgM monoclonal gammopathy, multiplex ligation-dependent probe 
      amplification (MLPA) assay in 18 of these patients and genome-wide-array-based 
      comparative genomic hybridization (CGH) in eight of these 18 patients. Four 
      patients had 10-20% and one patient had 30% B cells with IgH rearrangements; one 
      patient had additional loss of 14qter; one patient had amplification of 6p and 
      loss of 6q. Cytogenetic aberrations may be found in one third of the patients 
      with neuropathy associated with IgM monoclonal gammopathy and are mainly 
      associated with indolent Waldenstrom's Macroglobulinemia.
FAU - Eurelings, Marijke
AU  - Eurelings M
AD  - Department of Neurology, the Rudolf Magnus Institute of Neuroscience, University 
      Medical Center Utrecht, The Netherlands. m.eurelings@neuro.azu.nl
FAU - Lokhorst, Henk M
AU  - Lokhorst HM
FAU - Notermans, Nicolette C
AU  - Notermans NC
FAU - Krijtenburg, Pieter Jaap
AU  - Krijtenburg PJ
FAU - Kessel, Berris van
AU  - Kessel Bv
FAU - Eleveld, Mark J
AU  - Eleveld MJ
FAU - Bloem, Andries
AU  - Bloem A
FAU - Wokke, John H
AU  - Wokke JH
FAU - Poot, Martin
AU  - Poot M
FAU - Buijs, Arjan
AU  - Buijs A
LA  - eng
PT  - Journal Article
DEP - 20070601
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Aged
MH  - B-Lymphocytes/immunology
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 14/*genetics
MH  - DNA Mutational Analysis
MH  - Female
MH  - Genetic Predisposition to Disease/*genetics
MH  - Genetic Testing
MH  - Genotype
MH  - Humans
MH  - Immunoglobulin M/*genetics/immunology
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Paraproteinemias/*genetics/immunology/physiopathology
MH  - Peripheral Nerves/immunology/physiopathology
MH  - Polyneuropathies/*genetics/immunology/physiopathology
MH  - Waldenstrom Macroglobulinemia/genetics/immunology/physiopathology
EDAT- 2007/06/05 09:00
MHDA- 2007/12/07 09:00
CRDT- 2007/06/05 09:00
PHST- 2006/10/23 00:00 [received]
PHST- 2007/04/12 00:00 [revised]
PHST- 2007/04/16 00:00 [accepted]
PHST- 2007/06/05 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2007/06/05 09:00 [entrez]
AID - S0022-510X(07)00288-2 [pii]
AID - 10.1016/j.jns.2007.04.022 [doi]
PST - ppublish
SO  - J Neurol Sci. 2007 Sep 15;260(1-2):124-31. doi: 10.1016/j.jns.2007.04.022. Epub 
      2007 Jun 1.