PMID- 17544395
OWN - NLM
STAT- MEDLINE
DCOM- 20070919
LR  - 20211203
IS  - 0014-4827 (Print)
IS  - 0014-4827 (Linking)
VI  - 313
IP  - 13
DP  - 2007 Aug 1
TI  - Oligodendrocyte ablation affects the coordinated interaction between granule and 
      Purkinje neurons during cerebellum development.
PG  - 2946-57
AB  - Oligodendrocytes (OLs) are the glial cells of the central nervous system (CNS) 
      classically known to be devoted to the formation of myelin sheaths around most 
      axons of the vertebrate brain. We have addressed the role of these cells during 
      cerebellar development, by ablating OLs in vivo. Previous analyses had indicated 
      that OL ablation during the first six postnatal days results into a striking 
      cerebellar phenotype, whose major features are a strong reduction of granule 
      neurons and aberrant Purkinje cells development. These two cell types are highly 
      interconnected during cerebellar development through the production of molecules 
      that help their proliferation, differentiation and maintenance. In this article, 
      we present data showing that OL ablation has major effects on the physiology of 
      Purkinje (PC) and granule cells (GC). In particular, OL ablation results into a 
      reduction of sonic hedgehog (Shh), Brain Derived Neurotrophic Factor (BDNF), and 
      Reelin (Rln) expression. These results indicate that absence of OLs profoundly 
      alters the normal cerebellar developmental program.
FAU - Collin, Ludovic
AU  - Collin L
AD  - Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue L Fries 
      67404, Illkirch, France.
FAU - Doretto, Sandrine
AU  - Doretto S
FAU - Malerba, Monica
AU  - Malerba M
FAU - Ruat, Martial
AU  - Ruat M
FAU - Borrelli, Emiliana
AU  - Borrelli E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070522
PL  - United States
TA  - Exp Cell Res
JT  - Experimental cell research
JID - 0373226
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (Dab1 protein, mouse)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Reelin Protein)
RN  - EC 2.7.1.21 (Thymidine Kinase)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 3.4.21.- (RELN protein, human)
RN  - EC 3.4.21.- (Reln protein, mouse)
RN  - EC 3.4.21.- (Serine Endopeptidases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/analysis/metabolism
MH  - Cell Adhesion Molecules, Neuronal/metabolism
MH  - *Cell Communication
MH  - Cerebellum/chemistry/cytology/*growth & development
MH  - Extracellular Matrix Proteins/metabolism
MH  - Hedgehog Proteins/analysis/metabolism
MH  - Humans
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Myelin Sheath/metabolism
MH  - Nerve Tissue Proteins/analysis/metabolism
MH  - Neurons/chemistry/*physiology
MH  - Oligodendroglia/*physiology
MH  - Purkinje Cells/chemistry/*physiology
MH  - Receptor, trkA/analysis/metabolism
MH  - Reelin Protein
MH  - Serine Endopeptidases/metabolism
MH  - Signal Transduction
MH  - Thymidine Kinase/genetics
EDAT- 2007/06/05 09:00
MHDA- 2007/09/20 09:00
CRDT- 2007/06/05 09:00
PHST- 2007/02/02 00:00 [received]
PHST- 2007/05/01 00:00 [revised]
PHST- 2007/05/02 00:00 [accepted]
PHST- 2007/06/05 09:00 [pubmed]
PHST- 2007/09/20 09:00 [medline]
PHST- 2007/06/05 09:00 [entrez]
AID - S0014-4827(07)00225-X [pii]
AID - 10.1016/j.yexcr.2007.05.003 [doi]
PST - ppublish
SO  - Exp Cell Res. 2007 Aug 1;313(13):2946-57. doi: 10.1016/j.yexcr.2007.05.003. Epub 
      2007 May 22.