PMID- 17545512
OWN - NLM
STAT- MEDLINE
DCOM- 20070817
LR  - 20211203
IS  - 1078-0432 (Print)
IS  - 1078-0432 (Linking)
VI  - 13
IP  - 11
DP  - 2007 Jun 1
TI  - The mammalian target of rapamycin signaling pathway: twists and turns in the road 
      to cancer therapy.
PG  - 3109-14
AB  - The immunosuppressive drug rapamycin played a key role in the functional 
      characterization of mammalian target of rapamycin (mTOR), an unusual protein 
      kinase that coordinates growth factor and nutrient availability with cell growth 
      and proliferation. Several rapamycin-related compounds are now in various stages 
      of clinical development as anticancer agents. This article highlights recent 
      advances in our understanding of the mTOR signaling pathway and the implications 
      of these findings for the clinical application of mTOR inhibitors in cancer 
      patients.
FAU - Abraham, Robert T
AU  - Abraham RT
AD  - Department of Oncology Discovery, Wyeth, Pearl River, New York 10960, USA. 
      Abrahar@wyeth.com
FAU - Gibbons, James J
AU  - Gibbons JJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Cancer Res
JT  - Clinical cancer research : an official journal of the American Association for 
      Cancer Research
JID - 9502500
RN  - 0 (Antineoplastic Agents)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Cell Enlargement
MH  - Cell Proliferation
MH  - *Gene Expression Regulation, Neoplastic
MH  - Genes, Fungal
MH  - Genotype
MH  - Humans
MH  - Models, Biological
MH  - Neoplasms/metabolism/*therapy
MH  - Phosphorylation
MH  - Protein Kinases/*metabolism
MH  - *Signal Transduction
MH  - TOR Serine-Threonine Kinases
RF  - 73
EDAT- 2007/06/05 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/06/05 09:00
PHST- 2007/06/05 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/06/05 09:00 [entrez]
AID - 13/11/3109 [pii]
AID - 10.1158/1078-0432.CCR-06-2798 [doi]
PST - ppublish
SO  - Clin Cancer Res. 2007 Jun 1;13(11):3109-14. doi: 10.1158/1078-0432.CCR-06-2798.