PMID- 17546429
OWN - NLM
STAT- MEDLINE
DCOM- 20070705
LR  - 20181113
IS  - 0957-4530 (Print)
IS  - 0957-4530 (Linking)
VI  - 18
IP  - 4
DP  - 2007 Apr
TI  - Mechanical properties and apatite forming ability of TiO2 nanoparticles/high 
      density polyethylene composite: Effect of filler content.
PG  - 661-8
AB  - Composite materials consisting of TiO(2) nanoparticles and high-density 
      polyethylene (HDPE), designated hereafter as TiO(2)/HDPE, were prepared by a 
      kneading and forming process. The effect of TiO(2) content on the mechanical 
      properties and apatite forming ability of these materials was studied. Increased 
      TiO(2) content resulted in an increase in bending strength, yield strength, 
      Young's modulus and compressive strength (bending strength = 68 MPa, yield 
      strength = 54 MPa, Young's modulus = 7 GPa, and compressive strength = 82 MPa) at 
      50 vol% TiO(2). The composite with 50 vol% TiO(2) shows a similar strength and 
      Young's modulus to human cortical bone. The TiO(2)/HDPE composites with different 
      TiO(2) contents were soaked at 36.5 degrees C for up to 14 days in a simulated 
      body fluid (SBF) whose ion concentrations were nearly equal to those of human 
      blood plasma. The apatite forming ability, which is indicative of bioactivity, 
      increased with TiO(2) content. Little apatite formation was observed for the 
      TiO(2)/HDPE composite with 20 vol% content. However, in the case of 40 vol% 
      TiO(2) content and higher, the apatite layers were formed on the surface of the 
      composites within 7 days. The most potent TiO(2) content for a bone-repairing 
      material was 50 vol%, judging from the mechanical and biological results. This 
      kind of bioactive material with similar mechanical properties to human cortical 
      bone is expected to be useful as a load bearing bone substitute in areas such as 
      the vertebra and cranium.
FAU - Hashimoto, Masami
AU  - Hashimoto M
AD  - Japan Fine Ceramics Center, 2-4-1 Mutsuno, Atsuta-ku, Nagoya, 456-8587, Japan.
FAU - Takadama, Hiroaki
AU  - Takadama H
FAU - Mizuno, Mineo
AU  - Mizuno M
FAU - Kokubo, Tadashi
AU  - Kokubo T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Mater Sci Mater Med
JT  - Journal of materials science. Materials in medicine
JID - 9013087
RN  - 0 (Apatites)
RN  - 0 (Biocompatible Materials)
RN  - 0 (Bone Substitutes)
RN  - 15FIX9V2JP (titanium dioxide)
RN  - 9002-88-4 (Polyethylene)
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Apatites/*chemistry
MH  - Biocompatible Materials/chemistry
MH  - Bone Substitutes/*chemistry
MH  - Compressive Strength
MH  - Nanoparticles/*chemistry
MH  - Particle Size
MH  - Polyethylene/*chemistry
MH  - Surface Properties
MH  - Temperature
MH  - Tensile Strength
MH  - Time Factors
MH  - Titanium/*chemistry
EDAT- 2007/06/05 09:00
MHDA- 2007/07/06 09:00
CRDT- 2007/06/05 09:00
PHST- 2004/12/23 00:00 [received]
PHST- 2005/10/21 00:00 [accepted]
PHST- 2007/06/05 09:00 [pubmed]
PHST- 2007/07/06 09:00 [medline]
PHST- 2007/06/05 09:00 [entrez]
AID - 10.1007/s10856-007-2317-1 [doi]
PST - ppublish
SO  - J Mater Sci Mater Med. 2007 Apr;18(4):661-8. doi: 10.1007/s10856-007-2317-1.