PMID- 17551351
OWN - NLM
STAT- MEDLINE
DCOM- 20070905
LR  - 20220410
IS  - 0951-7367 (Print)
IS  - 0951-7367 (Linking)
VI  - 20
IP  - 4
DP  - 2007 Jul
TI  - Age of onset of mental disorders: a review of recent literature.
PG  - 359-64
AB  - PURPOSE OF REVIEW: The aim of this article is to review recent epidemiological 
      research on age-of-onset of mental disorders, focusing on the WHO World Mental 
      Health surveys. RECENT FINDINGS: Median and inter-quartile range (IQR; 25th-75th 
      percentiles) of age-of-onset is much earlier for phobias (7-14, IQR 4-20) and 
      impulse-control disorders (7-15; IQR 4-35) than other anxiety disorders (25-53, 
      IQR 15-75), mood disorders (25-45, IQR 17-65), and substance disorders (18-29, 
      IQR 16-43). Although less data exist for nonaffective psychosis, available 
      evidence suggests that median age-of-onset is in the range late teens through 
      early 20s. Roughly half of all lifetime mental disorders in most studies start by 
      the mid-teens and three quarters by the mid-20s. Later onsets are mostly 
      secondary conditions. Severe disorders are typically preceded by less severe 
      disorders that are seldom brought to clinical attention. SUMMARY: First onset of 
      mental disorders usually occur in childhood or adolescence, although treatment 
      typically does not occur until a number of years later. Although interventions 
      with early incipient disorders might help reduce severity-persistence of primary 
      disorders and prevent secondary disorders, additional research is needed on 
      appropriate treatments for early incipient cases and on long-term evaluation of 
      the effects of early intervention on secondary prevention.
FAU - Kessler, Ronald C
AU  - Kessler RC
AD  - Department of Healthcare Policy, Harvard Medical School, Boston, MA 02115, USA. 
      kessler@hcp.med.harvard.edu
FAU - Amminger, G Paul
AU  - Amminger GP
FAU - Aguilar-Gaxiola, Sergio
AU  - Aguilar-Gaxiola S
FAU - Alonso, Jordi
AU  - Alonso J
FAU - Lee, Sing
AU  - Lee S
FAU - Ustun, T Bedirhan
AU  - Ustun TB
LA  - eng
GR  - R01 DA016558/DA/NIDA NIH HHS/United States
GR  - R01-MH070884/MH/NIMH NIH HHS/United States
GR  - R01 MH069864/MH/NIMH NIH HHS/United States
GR  - R01 MH069864-04/MH/NIMH NIH HHS/United States
GR  - R01-DA016558/DA/NIDA NIH HHS/United States
GR  - R01-MH069864/MH/NIMH NIH HHS/United States
GR  - R01 AI087508/AI/NIAID NIH HHS/United States
GR  - R13 MH066849-05/MH/NIMH NIH HHS/United States
GR  - K05 DA015799/DA/NIDA NIH HHS/United States
GR  - R01 DA016558-04/DA/NIDA NIH HHS/United States
GR  - R13-MH066849/MH/NIMH NIH HHS/United States
GR  - R01 MH070884-02/MH/NIMH NIH HHS/United States
GR  - R01 MH070884/MH/NIMH NIH HHS/United States
GR  - U13 MH066849/MH/NIMH NIH HHS/United States
GR  - R13 MH066849/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Psychiatry
JT  - Current opinion in psychiatry
JID - 8809880
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Anxiety Disorders/epidemiology
MH  - Disruptive, Impulse Control, and Conduct Disorders/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Mental Disorders/*epidemiology
MH  - Middle Aged
MH  - Mood Disorders/epidemiology
MH  - Phobic Disorders/epidemiology
MH  - Psychotic Disorders/epidemiology
MH  - Severity of Illness Index
MH  - Substance-Related Disorders/epidemiology
PMC - PMC1925038
MID - NIHMS25081
EDAT- 2007/06/07 09:00
MHDA- 2007/09/06 09:00
PMCR- 2008/04/01
CRDT- 2007/06/07 09:00
PHST- 2007/06/07 09:00 [pubmed]
PHST- 2007/09/06 09:00 [medline]
PHST- 2007/06/07 09:00 [entrez]
PHST- 2008/04/01 00:00 [pmc-release]
AID - 00001504-200707000-00010 [pii]
AID - 10.1097/YCO.0b013e32816ebc8c [doi]
PST - ppublish
SO  - Curr Opin Psychiatry. 2007 Jul;20(4):359-64. doi: 10.1097/YCO.0b013e32816ebc8c.