PMID- 17551749
OWN - NLM
STAT- MEDLINE
DCOM- 20071121
LR  - 20181113
IS  - 1439-6319 (Print)
IS  - 1439-6319 (Linking)
VI  - 101
IP  - 2
DP  - 2007 Sep
TI  - Evidence of sex-based differences in natural killer cell responses to exercise 
      and carbohydrate intake in children.
PG  - 233-40
AB  - Distinct natural killer (NK) cell subsets (CD56bright and CD56dim) are mobilized 
      with exercise and these cells may serve adaptive functions. We determined the 
      distribution of NK cell subsets in response to exercise and carbohydrate (CHO) 
      intake in young girls and compared these responses with previous findings in 
      young boys of the same age. Twelve girls (12 years old) cycled for 60 min at 70% 
      VO2max while drinking 6% CHO or flavoured water. Blood was collected at rest, 
      during (30 and 60 min) and following (30 and 60 min) exercise to identify NK 
      cells as CD3-CD56bright or CD3-CD56dim. CD69 expression on total CD3-CD56+ cells 
      was also determined. A trend (P=0.07) was found for a trial x time interaction in 
      CD56dim cell counts, with values lower with CHO than with water. CHO intake did 
      not influence CD56bright responses (P>or=0.39). The CD56bright:CD56dim ratio 
      increased during recovery from exercise (P<0.001), compared to rest, with no 
      effect of CHO intake (P=0.48). CD69 expression was not different between exercise 
      or recovery and rest. Like young boys, girls experience an elevated 
      CD56bright:CD56dim ratio during recovery from exercise and CHO intake attenuates 
      the exercise-induced CD56dim but not CD56bright cell response. Unlike young boys, 
      girls do not experience a CHO-induced increase in the CD56bright:CD56dim ratio 
      during recovery and CD69 expression does not increase on CD3-CD56+ cells during 
      recovery. We conclude that even in young children sex-based differences exist in 
      the NK cell response to exercise and CHO intake.
FAU - Timmons, Brian W
AU  - Timmons BW
AD  - Children's Exercise and Nutrition Centre, Departments of Pediatrics, McMaster 
      University, Hamilton, ON, Canada. timmonbw@mcmaster.ca
FAU - Bar-Or, Oded
AU  - Bar-Or O
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070606
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
RN  - 0 (Antigens, CD)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (Blood Glucose)
RN  - 0 (CD56 Antigen)
RN  - 0 (CD69 antigen)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Lectins, C-Type)
RN  - 9002-72-6 (Growth Hormone)
RN  - WI4X0X7BPJ (Hydrocortisone)
RN  - X4W3ENH1CV (Norepinephrine)
RN  - YKH834O4BH (Epinephrine)
SB  - IM
MH  - Antigens, CD/metabolism
MH  - Antigens, Differentiation, T-Lymphocyte/metabolism
MH  - Blood Glucose/metabolism
MH  - CD56 Antigen/metabolism
MH  - Child
MH  - Dietary Carbohydrates/metabolism/*pharmacology
MH  - Epinephrine/blood
MH  - Exercise/*physiology
MH  - Female
MH  - Growth Hormone/blood
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Killer Cells, Natural/drug effects/*immunology
MH  - Lectins, C-Type
MH  - Norepinephrine/blood
MH  - Sex Factors
EDAT- 2007/06/07 09:00
MHDA- 2007/12/06 09:00
CRDT- 2007/06/07 09:00
PHST- 2007/05/14 00:00 [accepted]
PHST- 2007/06/07 09:00 [pubmed]
PHST- 2007/12/06 09:00 [medline]
PHST- 2007/06/07 09:00 [entrez]
AID - 10.1007/s00421-007-0495-7 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2007 Sep;101(2):233-40. doi: 10.1007/s00421-007-0495-7. Epub 
      2007 Jun 6.