PMID- 17552991
OWN - NLM
STAT- MEDLINE
DCOM- 20070815
LR  - 20161124
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 25
IP  - 11
DP  - 2007 Jun
TI  - Ethanol reverses the direction of long-term synaptic plasticity in the 
      dorsomedial striatum.
PG  - 3226-32
AB  - The striatum is a critical structure for the control of voluntary behaviour, and 
      striatal synaptic plasticity has been implicated in instrumental learning. As 
      ethanol consumption can cause impairments in cognition, learning, and action 
      selection, it is important to understand the effects of this drug on striatal 
      function. In this study we examined the effects of ethanol on long-term synaptic 
      plasticity in the dorsomedial striatum (DMS), a striatal subregion that plays a 
      central role in the acquisition and selection of goal-directed actions. Ethanol 
      was found to impair N-methyl-d-aspartic acid receptor (NMDAR)-dependent long-term 
      potentiation (LTP) dose-dependently in the DMS, and to promote long-term 
      depression (LTD) at the highest concentration (50 mm) used. These results suggest 
      that ethanol, at a concentration usually associated with mild intoxication, could 
      significantly change experience-dependent modification of corticostriatal 
      circuits underlying the learning of goal-directed instrumental actions.
FAU - Yin, Henry H
AU  - Yin HH
AD  - Section on Synaptic Pharmacology, Laboratory for Integrative Neuroscience, 
      NIAAA/NIH, 5625 Fishers Lane, TS-13, Bethesda, Maryland 20892, USA.
FAU - Park, Brian S
AU  - Park BS
FAU - Adermark, Louise
AU  - Adermark L
FAU - Lovinger, David M
AU  - Lovinger DM
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Central Nervous System Depressants)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Piperidines)
RN  - 0 (Pyrazoles)
RN  - 3I4FA44MAI (AM 251)
RN  - 3K9958V90M (Ethanol)
RN  - 7MNE9M8287 (Sulpiride)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Central Nervous System Depressants/*pharmacology
MH  - Corpus Striatum/*cytology
MH  - Dopamine Antagonists/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Dose-Response Relationship, Radiation
MH  - Electric Stimulation
MH  - Ethanol/*pharmacology
MH  - Evoked Potentials/drug effects/physiology/radiation effects
MH  - In Vitro Techniques
MH  - Neuronal Plasticity/*drug effects
MH  - Neurons/*drug effects/physiology
MH  - Patch-Clamp Techniques/methods
MH  - Piperidines/pharmacology
MH  - Pyrazoles/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Sulpiride/pharmacology
MH  - Synaptic Transmission/*drug effects/physiology
MH  - Time Factors
EDAT- 2007/06/08 09:00
MHDA- 2007/08/19 09:00
CRDT- 2007/06/08 09:00
PHST- 2007/06/08 09:00 [pubmed]
PHST- 2007/08/19 09:00 [medline]
PHST- 2007/06/08 09:00 [entrez]
AID - EJN5606 [pii]
AID - 10.1111/j.1460-9568.2007.05606.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2007 Jun;25(11):3226-32. doi: 10.1111/j.1460-9568.2007.05606.x.