PMID- 17553306
OWN - NLM
STAT- MEDLINE
DCOM- 20081021
LR  - 20070607
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 87
IP  - 10
DP  - 2007 Mar 13
TI  - [Autologous mononuclear bone marrow cell transplantation by intracoronary route 
      for patients with ischemic heart disease: observation of 2-years follow-up].
PG  - 685-9
AB  - OBJECTIVE: To investigate the long-term effect and safety of intracoronary 
      autologous bone marrow mononuclear cell (BMMC) transplantation in patients with 
      ischemic heart disease (IHD). METHODS: Seventy-six patients with IHD, 26 patients 
      with acute myocardial infarction (AMI) and 26 patients with chronic ischemic 
      heart failure (CIHF), underwent routine treatment plus intracoronary autologous 
      BMMC transplantation, and 24 patients, including 10 patients with AMI and 14 
      patients with CIHF underwent routine treatment as controls. Autologous BMMC 
      transplantation was performed via a balloon catheter placed into the 
      infarct-related artery during balloon dilatation by high pressure infusion to 
      occlude the artery, which was performed 6 - 8 times for 2 minutes each with 
      2-minute interval or via a balloon catheter without occluding the infarct-related 
      artery. Follow-up was conducted for 2 years. RESULTS: The surgery was safety 
      without major periprocedural complications. There were no other new arrhythmias 
      found by Holter recorder during the 2-years follow-up. In the AMI patients 
      receiving BNNC transplantation, the left ventricular ejection fraction (LVEF) 1 
      and 2 years later increased by 5.79% (P < 0.05), 3.79% (P > 0.05) respectively; 
      but there was no change in left ventricular end diastolic volume (LVEDV) and left 
      ventricular end systolic volume (LVESV). The LVEF 1 and 2 years later of the 
      control group increased by 8.8% and 9.2% respectively (both P < 0.01) and the 
      LVESV 1 and 2 years later decreased by 20.4% and 27.8% respectively (both P < 
      0.05), the myocardium defect area 2 years later was not significantly different 
      from that 3 months later. The heart function of the control group became markedly 
      worse. CONCLUSION: Autologous BMMC intracoronary transplantation is safe and 
      effective, especially in patients with CIHF.
FAU - Gao, Lian-Ru
AU  - Gao LR
AD  - Department of Cardiology, General Hospital of Naval General Hospital of the 
      Chinese People's Liberation Army, Beijing 100037, China.
FAU - Wang, Zhi-Guo
AU  - Wang ZG
FAU - Tian, Hai-Tao
AU  - Tian HT
FAU - Zhu, Zhi-Ming
AU  - Zhu ZM
FAU - Fei, Yu-Xing
AU  - Fei YX
FAU - Xu, Hong-Tao
AU  - Xu HT
FAU - Chen, Yu
AU  - Chen Y
FAU - Zhu, Jia-Rui
AU  - Zhu JR
FAU - He, Sheng
AU  - He S
FAU - Zhang, Ning-Kun
AU  - Zhang NK
FAU - Ding, Qing-Ai
AU  - Ding QA
FAU - Yang, Ye
AU  - Yang Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Aged
MH  - Bone Marrow Cells/cytology
MH  - Bone Marrow Transplantation/*methods
MH  - Coronary Vessels/surgery
MH  - Follow-Up Studies
MH  - Humans
MH  - Leukocytes, Mononuclear/cytology/transplantation
MH  - Middle Aged
MH  - Myocardial Ischemia/*surgery
MH  - Transplantation, Autologous
EDAT- 2007/06/08 09:00
MHDA- 2008/10/22 09:00
CRDT- 2007/06/08 09:00
PHST- 2007/06/08 09:00 [pubmed]
PHST- 2008/10/22 09:00 [medline]
PHST- 2007/06/08 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2007 Mar 13;87(10):685-9.