PMID- 17553343
OWN - NLM
STAT- MEDLINE
DCOM- 20090430
LR  - 20200113
IS  - 1007-8738 (Print)
IS  - 1007-8738 (Linking)
VI  - 23
IP  - 6
DP  - 2007 Jun
TI  - [Differential expression of USP2, USP14 and UBE4A between ovarian serous 
      cystadenocarcinoma and adjacent normal tissues].
PG  - 504-6
AB  - AIM: The differential expression of USP2, USP14 and UBE4A between ovarian serous 
      cystadenocarcinoma and adjacent normal tissues was investigated. METHODS: 
      Restriction fragment differential display polymerase chain reaction (RFDD-PCR), 
      semi-quantitative RT-PCR and immunohistochemical staining were applied to analyze 
      the differentially expressed genes and proteins of ubiquitin specific proteases 
      (USPs), USP2 and USP14, and ubiquitin factor E4A (UBE4A) between ovarian serous 
      cystadenocarcinoma and adjacent normal tissues obtained from 40 patients aged 
      from 29 to 72 years old, collected in 2005 year at excision of surgical operation 
      with ovarian serous cystadenocarcinoma. RESULTS: USP2, USP14 and UBE4A were 
      over-expressed (>3 folds) in ovarian serous cystadenocarcinoma tissues compared 
      to normal tissues. CONCLUSION: The results suggest that the activity of 
      ubiquitin-proteasome system is obviously enhanced in ovarian cancer.
FAU - Yang, Ying
AU  - Yang Y
AD  - Department of Anatomy, West China School of Preclinical and Forensic Medicine, 
      Sichuan University, Chengdu 610041, China.
FAU - Hou, Jian-qing
AU  - Hou JQ
FAU - Qu, Lu-yun
AU  - Qu LY
FAU - Wang, Gui-qing
AU  - Wang GQ
FAU - Ju, Hong-wei
AU  - Ju HW
FAU - Zhao, Zhi-wei
AU  - Zhao ZW
FAU - Yu, Zhen-hai
AU  - Yu ZH
FAU - Yang, Hui-jun
AU  - Yang HJ
LA  - chi
PT  - Journal Article
PL  - China
TA  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
JT  - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular 
      immunology
JID - 101139110
RN  - 0 (USP14 protein, human)
RN  - EC 2.3.2.27 (UBE4A protein, human)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 3.4.- (Endopeptidases)
RN  - EC 3.4.19.12 (USP2 protein, human)
RN  - EC 3.4.19.12 (Ubiquitin Thiolesterase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cystadenocarcinoma, Serous/*metabolism/pathology
MH  - Endopeptidases/genetics/*metabolism
MH  - Female
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Middle Aged
MH  - Ovarian Neoplasms/*metabolism
MH  - Polymerase Chain Reaction
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Ubiquitin Thiolesterase/genetics/*metabolism
MH  - Ubiquitin-Protein Ligases/genetics/*metabolism
EDAT- 2007/06/08 09:00
MHDA- 2009/05/01 09:00
CRDT- 2007/06/08 09:00
PHST- 2007/06/08 09:00 [pubmed]
PHST- 2009/05/01 09:00 [medline]
PHST- 2007/06/08 09:00 [entrez]
PST - ppublish
SO  - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007 Jun;23(6):504-6.