PMID- 17553570
OWN - NLM
STAT- MEDLINE
DCOM- 20080430
LR  - 20220409
IS  - 0165-0327 (Print)
IS  - 0165-0327 (Linking)
VI  - 105
IP  - 1-3
DP  - 2008 Jan
TI  - Plasma and serum brain-derived neurotrophic factor (BDNF) in depressed patients 
      during 1 year of antidepressant treatments.
PG  - 279-83
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) has been hypothesized to be 
      involved in the neurobiology of major depression. The aim of this study was to 
      assess the possible relationships between depressive symptoms and serum and/or 
      plasma BDNF levels during 1 year of antidepressant treatment. METHODS: Plasma and 
      serum BDNF levels were assayed in 15 drug-free depressed patients and in 15 
      healthy control subjects at baseline and the 1st, 3rd, 6th and 12th month of 
      antidepressant treatment. RESULTS: At baseline, patients' serum and plasma BDNF 
      levels were significantly lower (p<.001 and p=.004, respectively) than those 
      found in healthy control subjects. However, while from the 1st month of treatment 
      patients' plasma BDNF levels did not differ significantly from those observed in 
      healthy control subjects, serum BDNF levels in patients remained significantly 
      lower at all times. LIMITATIONS: The main limitations of the current study are 
      represented by the small sample size and the high discontinuation rate. 
      CONCLUSIONS: Untreated depressed patients showed reduced baseline serum and 
      plasma BDNF levels, as compared with control subjects. The clinical improvement 
      paralleled the normalization of plasma BDNF after 1 month of treatment, while, at 
      every assessment time, patients' serum BDNF levels were lower than those of 
      control subjects. This would suggest that serum BDNF might represent a 
      non-specific trait marker of depression.
FAU - Piccinni, Armando
AU  - Piccinni A
AD  - Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, 
      University of Pisa, Pisa, Italy. a.piccini@med.unipi.it
FAU - Marazziti, Donatella
AU  - Marazziti D
FAU - Catena, Mario
AU  - Catena M
FAU - Domenici, Luciano
AU  - Domenici L
FAU - Del Debbio, Alessandro
AU  - Del Debbio A
FAU - Bianchi, Carolina
AU  - Bianchi C
FAU - Mannari, Claudio
AU  - Mannari C
FAU - Martini, Claudia
AU  - Martini C
FAU - Da Pozzo, Eleonora
AU  - Da Pozzo E
FAU - Schiavi, Elisa
AU  - Schiavi E
FAU - Mariotti, Alessandra
AU  - Mariotti A
FAU - Roncaglia, Isabella
AU  - Roncaglia I
FAU - Palla, Agnese
AU  - Palla A
FAU - Consoli, Giorgio
AU  - Consoli G
FAU - Giovannini, Luca
AU  - Giovannini L
FAU - Massimetti, Gabriele
AU  - Massimetti G
FAU - Dell'Osso, Liliana
AU  - Dell'Osso L
LA  - eng
PT  - Journal Article
DEP - 20070605
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Antidepressive Agents/*therapeutic use
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Depressive Disorder, Major/*blood/diagnosis/*drug therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Time Factors
EDAT- 2007/06/08 09:00
MHDA- 2008/05/01 09:00
CRDT- 2007/06/08 09:00
PHST- 2007/03/12 00:00 [received]
PHST- 2007/05/07 00:00 [revised]
PHST- 2007/05/07 00:00 [accepted]
PHST- 2007/06/08 09:00 [pubmed]
PHST- 2008/05/01 09:00 [medline]
PHST- 2007/06/08 09:00 [entrez]
AID - S0165-0327(07)00176-0 [pii]
AID - 10.1016/j.jad.2007.05.005 [doi]
PST - ppublish
SO  - J Affect Disord. 2008 Jan;105(1-3):279-83. doi: 10.1016/j.jad.2007.05.005. Epub 
      2007 Jun 5.