PMID- 17553627
OWN - NLM
STAT- MEDLINE
DCOM- 20080502
LR  - 20151119
IS  - 0306-9877 (Print)
IS  - 0306-9877 (Linking)
VI  - 70
IP  - 2
DP  - 2008
TI  - Bioinformatics analysis of functional protein sequences reveals a role for 
      brain-derived neurotrophic factor in obesity and type 2 diabetes mellitus.
PG  - 424-9
AB  - Using bioinformatics techniques and sequence analyses algorithms, a comparative 
      study between human and rodents revealed similarity in the behavior of genes 
      involved in the control of energy homeostasis. Brain-derived neurotrophic factor 
      (BDNF) modulates the secretion and actions of insulin, leptin, ghrelin, various 
      neurotransmitters and peptides, and pro-inflammatory cytokines involved in energy 
      homeostasis suggesting that it (BDNF) has a significant role in the pathobiology 
      of obesity and type 2 diabetes mellitus. Based on these evidences, we propose 
      that obesity and type 2 diabetes could be disorders of the brain and BDNF could 
      serve as a biomarker in predicting their development. Hence, methods developed to 
      selectively deliver BDNF to appropriate hypothalamic neurons may form a novel 
      approach in their treatment.
FAU - Rao, Allam Appa
AU  - Rao AA
AD  - Department of Computer Science and Systems Engineering, Andhra University, 
      Visakhapatnam 530 003, India.
FAU - Sridhar, Gumpeny R
AU  - Sridhar GR
FAU - Srinivas, Bolem
AU  - Srinivas B
FAU - Das, Undurti N
AU  - Das UN
LA  - eng
PT  - Journal Article
DEP - 20070605
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ghrelin)
RN  - 0 (Insulin)
RN  - 0 (Leptin)
RN  - 0 (Melanocortins)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Brain/physiopathology
MH  - Brain-Derived Neurotrophic Factor/*genetics/*physiology
MH  - Computational Biology
MH  - Diabetes Mellitus, Type 2/*etiology/genetics/physiopathology
MH  - Energy Metabolism
MH  - Ghrelin/physiology
MH  - Homeostasis
MH  - Humans
MH  - Insulin/physiology
MH  - Leptin/physiology
MH  - Melanocortins/physiology
MH  - Mice
MH  - Models, Biological
MH  - Obesity/*etiology/genetics/physiopathology
MH  - Phylogeny
MH  - Sequence Alignment
MH  - Species Specificity
EDAT- 2007/06/08 09:00
MHDA- 2008/05/03 09:00
CRDT- 2007/06/08 09:00
PHST- 2007/03/12 00:00 [received]
PHST- 2007/03/12 00:00 [accepted]
PHST- 2007/06/08 09:00 [pubmed]
PHST- 2008/05/03 09:00 [medline]
PHST- 2007/06/08 09:00 [entrez]
AID - S0306-9877(07)00277-0 [pii]
AID - 10.1016/j.mehy.2007.03.034 [doi]
PST - ppublish
SO  - Med Hypotheses. 2008;70(2):424-9. doi: 10.1016/j.mehy.2007.03.034. Epub 2007 Jun 
      5.