PMID- 17553842
OWN - NLM
STAT- MEDLINE
DCOM- 20071017
LR  - 20200930
IS  - 0363-6119 (Print)
IS  - 0363-6119 (Linking)
VI  - 293
IP  - 3
DP  - 2007 Sep
TI  - Brain-derived neurotrophic factor in the ventromedial nucleus of the hypothalamus 
      reduces energy intake.
PG  - R1037-45
AB  - Recent studies show that brain-derived neurotrophic factor (BDNF) decreases 
      feeding and body weight after peripheral and ventricular administration. BDNF 
      mRNA and protein, and its receptor TrkB, are widely distributed in the 
      hypothalamus and other brain regions. However, there are few reports on specific 
      brain sites of actions for BDNF. We evaluated the effect of BDNF, given into the 
      ventromedial nucleus of the hypothalamus (VMH), on normal and deprivation- and 
      neuropeptide Y (NPY)-induced feeding behavior and body weight. BDNF injected 
      unilaterally or bilaterally into the VMH of food-deprived and nondeprived rats 
      significantly decreased feeding and body weight gain within the 0- to 24-h and 
      the 24- to 48-h postinjection intervals. Doses effectively producing inhibition 
      of feeding behavior did not establish a conditioned taste aversion. BDNF-induced 
      feeding inhibition was attenuated by pretreatment of the TrkB-Fc fusion protein 
      that blocks binding between BDNF and its receptor TrkB. VMH-injected BDNF 
      significantly decreased VMH NPY-induced feeding at 1, 2, and 4 h after injection. 
      In summary, BDNF in the VMH significantly decreases food intake and body weight 
      gain, by TrkB receptor-mediated actions. Furthermore, the anorectic effects of 
      BDNF in this site appear to be mediated by NPY. These data suggest that the VMH 
      is an important site of action for BDNF in its effects on energy metabolism.
FAU - Wang, ChuanFeng
AU  - Wang C
AD  - Veterans Affairs Medical Center, Research Service (151) One Veterans Drive, 
      Minneapolis, MN 55417, USA. cwang@umn.edu
FAU - Bomberg, Eric
AU  - Bomberg E
FAU - Levine, Allen
AU  - Levine A
FAU - Billington, Charles
AU  - Billington C
FAU - Kotz, Catherine M
AU  - Kotz CM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20070606
PL  - United States
TA  - Am J Physiol Regul Integr Comp Physiol
JT  - American journal of physiology. Regulatory, integrative and comparative 
      physiology
JID - 100901230
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuropeptide Y)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - FST467XS7D (Saccharin)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Eating/drug effects
MH  - Energy Intake/*drug effects
MH  - Feeding Behavior/drug effects
MH  - Food Deprivation/physiology
MH  - Food Preferences/drug effects
MH  - Male
MH  - Neuropeptide Y/antagonists & inhibitors/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/drug effects
MH  - Saccharin/pharmacology
MH  - Taste/drug effects
MH  - Ventromedial Hypothalamic Nucleus/*physiology
MH  - Weight Gain/drug effects
EDAT- 2007/06/08 09:00
MHDA- 2007/10/18 09:00
CRDT- 2007/06/08 09:00
PHST- 2007/06/08 09:00 [pubmed]
PHST- 2007/10/18 09:00 [medline]
PHST- 2007/06/08 09:00 [entrez]
AID - 00125.2007 [pii]
AID - 10.1152/ajpregu.00125.2007 [doi]
PST - ppublish
SO  - Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1037-45. doi: 
      10.1152/ajpregu.00125.2007. Epub 2007 Jun 6.