PMID- 17556074
OWN - NLM
STAT- MEDLINE
DCOM- 20070822
LR  - 20070608
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 175
IP  - 2
DP  - 2007 Jun
TI  - Incidence of submicroscopic deletions vary according to disease entities and 
      chromosomal translocations in hematologic malignancies: investigation by 
      fluorescence in situ hybridization.
PG  - 166-8
AB  - Submicroscopic deletions of genes in recurrent chromosomal rearrangements occur 
      frequently in hematologic malignancies, but their incidences have not been 
      reported clearly. We investigated the incidence of submicroscopic deletions and 
      their association with specific genetic rearrangements in various hematologic 
      malignancies. A fluorescence in situ hybridization (FISH) study was conducted in 
      336 patients with acute lymphoblastic leukemia, 223 patients with acute myeloid 
      leukemia, and 79 patients with chronic myelogenous leukemia. The incidence of 
      submicroscopic deletions in patients with chromosomal rearrangements was the 
      highest in the TEL/AML1 rearrangement (65.0%), followed by BCR/ABL (10.9%), MLL 
      (5.6%), AML/ETO (4.0%), and PML/RARA (0.0%). Submicroscopic deletion was quite 
      common, and incidences were variable according to disease entities and 
      chromosomal translocations. To detect submicroscopic deletions, careful FISH 
      study should be included for the cytogenetic study of hematologic malignancies, 
      and their association with clinical prognosis needs to be further studied.
FAU - Moon, Hee Won
AU  - Moon HW
AD  - Department of Laboratory Medicine, Ewha Womans University College of Medicine, 
      Seoul, Korea.
FAU - Chang, Yoon Hwan
AU  - Chang YH
FAU - Kim, Tae Young
AU  - Kim TY
FAU - Oh, Bo Ra
AU  - Oh BR
FAU - Min, Hyun Chung
AU  - Min HC
FAU - Kim, Byoung Kook
AU  - Kim BK
FAU - Ahn, Hyo Seop
AU  - Ahn HS
FAU - Cho, Han Ik
AU  - Cho HI
FAU - Lee, Dong Soon
AU  - Lee DS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (TEL-AML1 fusion protein)
SB  - IM
MH  - *Chromosome Deletion
MH  - Core Binding Factor Alpha 2 Subunit/genetics
MH  - Hematologic Neoplasms/*genetics
MH  - Humans
MH  - *In Situ Hybridization, Fluorescence
MH  - Oncogene Proteins, Fusion/genetics
MH  - *Translocation, Genetic
EDAT- 2007/06/09 09:00
MHDA- 2007/08/23 09:00
CRDT- 2007/06/09 09:00
PHST- 2006/12/19 00:00 [received]
PHST- 2007/01/19 00:00 [revised]
PHST- 2007/01/29 00:00 [accepted]
PHST- 2007/06/09 09:00 [pubmed]
PHST- 2007/08/23 09:00 [medline]
PHST- 2007/06/09 09:00 [entrez]
AID - S0165-4608(07)00074-X [pii]
AID - 10.1016/j.cancergencyto.2007.01.012 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2007 Jun;175(2):166-8. doi: 
      10.1016/j.cancergencyto.2007.01.012.