PMID- 17559164
OWN - NLM
STAT- MEDLINE
DCOM- 20071024
LR  - 20131121
IS  - 0749-1581 (Print)
IS  - 0749-1581 (Linking)
VI  - 45
IP  - 8
DP  - 2007 Aug
TI  - Structure elucidation of thermal degradation products of amlodipine.
PG  - 688-91
AB  - Thermal degradation of amlodipine base causes intramolecular reactions affording 
      three cyclic products, referred to as AMLDEG-I, AMLDEG-II, and AMLDEG-III, 
      respectively. AMLDEG-I is a cyclized product formed by intramolecular elimination 
      of ammonia from amlodipine. AMLDEG-II is a positional isomer of AMLDEG-I. 
      AMLDEG-III is also intramolecular cyclisation product. The three degradation 
      products were isolated by column chromatography and characterized by FT-IR and 1H 
      and 13C NMR spectroscopy data. The AMLDEG-III was crystallized and its structure 
      was solved by single crystal X-ray diffraction (SXRD).
CI  - Copyright 2007 John Wiley & Sons, Ltd.
FAU - Lakshmi Devi, A Siva
AU  - Lakshmi Devi AS
AD  - Analytical Research and Development, Matrix Laboratories Ltd., Jeedimetla, 
      Hyderabad, India-500055, India. sivalakshmi@matrixlabsindia.com
FAU - Srinivasa Rao, Y
AU  - Srinivasa Rao Y
FAU - Satish, M
AU  - Satish M
FAU - Jyothi, G
AU  - Jyothi G
FAU - Babu Rao, K
AU  - Babu Rao K
FAU - Omdutt, T
AU  - Omdutt T
LA  - eng
PT  - Journal Article
PL  - England
TA  - Magn Reson Chem
JT  - Magnetic resonance in chemistry : MRC
JID - 9882600
RN  - 1J444QC288 (Amlodipine)
SB  - IM
MH  - Amlodipine/*chemistry
MH  - Cyclization
MH  - *Hot Temperature
MH  - *Magnetic Resonance Spectroscopy
MH  - Molecular Structure
MH  - X-Ray Diffraction
EDAT- 2007/06/15 09:00
MHDA- 2007/10/25 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/10/25 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - 10.1002/mrc.2022 [doi]
PST - ppublish
SO  - Magn Reson Chem. 2007 Aug;45(8):688-91. doi: 10.1002/mrc.2022.