PMID- 17559565
OWN - NLM
STAT- MEDLINE
DCOM- 20071004
LR  - 20081121
IS  - 0956-5507 (Print)
IS  - 0956-5507 (Linking)
VI  - 18
IP  - 4
DP  - 2007 Aug
TI  - The complex cytological features of synovial sarcoma in fine needle aspirates, an 
      analysis of four illustrative cases.
PG  - 234-40
AB  - OBJECTIVE: The cytological features of conventional monophasic spindle cell and 
      biphasic synovial sarcoma have been defined in detail in several large series. 
      The cytology of rare morphological variants, especially the subtypes of poorly 
      differentiated synovial sarcoma, are insufficiently evaluated and diagnostically 
      difficult to define. The objective of the present study was to call attention to 
      the variable cytology of rare variants of synovial sarcoma. Furthermore, 
      adjunctive diagnostic methods, necessary for a correct diagnosis, are discussed. 
      METHODS: Aspirates from four synovial sarcomas, with cytological features, which 
      differed from those of conventional synovial sarcoma and from each other, were 
      retrieved from our files and re-evaluated. RESULTS: In three of the cases a 
      correct diagnosis was not obtained from routinely stained aspirates. In the 
      fourth case, the correct diagnosis was established by a combination of 
      cytomorphology, immunocytochemistry and fluorescence in situ hybridization (FISH) 
      performed on the aspirated material. CONCLUSION: Ancillary diagnostic methods are 
      necessary in the examination of aspiration smears from synovial sarcoma, 
      especially of morphological variants with a cytomorphology that differs from 
      conventional spindle-cell monophasic and biphasic tumours. Immunocytochemistry 
      and molecular genetic examinations (reverse transcriptase polymerase chain 
      reaction or FISH) are the methods of choice.
FAU - Akerman, M
AU  - Akerman M
AD  - Department of Pathology and Cytology, Lund University Hospital, Lund, Sweden. 
      mans.akerman@skane.se
FAU - Domanski, H A
AU  - Domanski HA
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20070608
PL  - England
TA  - Cytopathology
JT  - Cytopathology : official journal of the British Society for Clinical Cytology
JID - 9010345
RN  - 0 (Mucin-1)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Repressor Proteins)
RN  - 0 (SS18 protein, human)
RN  - 164289-47-8 (synovial sarcoma X breakpoint proteins)
RN  - 68238-35-7 (Keratins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Biopsy, Fine-Needle
MH  - Cytodiagnosis/methods
MH  - Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Keratins/analysis
MH  - Male
MH  - Mucin-1/analysis
MH  - Neoplasm Proteins/genetics
MH  - Proto-Oncogene Proteins/genetics
MH  - Repressor Proteins/genetics
MH  - Sarcoma, Synovial/genetics/metabolism/*pathology
MH  - Synovial Membrane/metabolism/*pathology
EDAT- 2007/06/15 09:00
MHDA- 2007/10/05 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/15 09:00 [pubmed]
PHST- 2007/10/05 09:00 [medline]
PHST- 2007/06/15 09:00 [entrez]
AID - CYT458 [pii]
AID - 10.1111/j.1365-2303.2007.00458.x [doi]
PST - ppublish
SO  - Cytopathology. 2007 Aug;18(4):234-40. doi: 10.1111/j.1365-2303.2007.00458.x. Epub 
      2007 Jun 8.